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IMMUNOLOGY Bios 328 a textbook-based study of immunology Spring 2003 http://www.lehigh.edu/~sk08/Courses/Bios328/mainpage.htm PowerPoint PPT Presentation


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IMMUNOLOGY Bios 328 a textbook-based study of immunology Spring 2003 http://www.lehigh.edu/~sk08/Courses/Bios328/mainpage.htm. Immunologic responses. Innate Acquired. Immunologic responses. Innate anatomic physiologic phagocytic inflammatory (acute, not chronic) Acquired …….

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IMMUNOLOGY Bios 328 a textbook-based study of immunology Spring 2003 http://www.lehigh.edu/~sk08/Courses/Bios328/mainpage.htm

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Immunology bios 328 a textbook based study of immunology spring 2003 http www lehigh edu sk08 courses bios328 mainpage htm

IMMUNOLOGY

Bios 328

a textbook-based study of immunology

Spring 2003

http://www.lehigh.edu/~sk08/Courses/Bios328/mainpage.htm


Immunologic responses

Immunologic responses

Innate

Acquired


Immunologic responses1

Immunologic responses

Innate

anatomic

physiologic

phagocytic

inflammatory (acute, not chronic)

Acquired

……


Innate immunologic response

Innate immunologic response

Anatomic: e. g., skin (!)

a barrier…

sometimes ciliated sometimes coated with mucous

sometimes bathed with fluids


Innate immunologic response1

Ciliated, coated, bathed…

What are the principal routes of entries of pathogens and other noxious agents?

Alimentary system

Respiratory system

Urogenital system

Innate immunologic response


Innate immunologic response2

Innate immunologic response

Ciliated, coated, bathed…

Ciliated: sweep entities away or into mucous

Coated: entrap entities; expel through coughing

Bathed: fluids flush… or serve as solvent for enzymes like lysozyme (which digests the near universal beta 1,4 glycosidic linkage between N-acetylmuramic acid and N-acetyl glucosamine in bacterial walls)

Other: fatty acids in skin (affect pH)


Innate immunologic response viz physiologic

Innate immunologic responseviz. physiologic

Other: fatty acids in skin (affect pH)

More “other”: numerous proteins

Interferons

Kinins

Fibrins

Complement


Immunologic response

Immunologic response

  • Skin… obviously “anatomic”

  • Fluids… phsyiologic (?)

  • Fatty acids… physiologic again

  • Phagocytic

    • Who does this?

      • Polymorphonuclear leukocytes (aka neutrophils)

      • Macrophages

  • Inflammation

    What is this?


Inflammation

Caldor

Rubor

Tumor

Dolor

HEAT

REDNESS

SWELLING

PAIN

Inflammation


Immunologic responses2

Immunologic responses

Innate

Acquired


Immunologic responses3

Immunologic responses

Innate

also called non-specific

Acquired

also called specific or adaptive


Immunologic responses4

Immunologic responses

Innate

Invariant… does not vary with stimulus

Acquired

Highly variable and has memory


Acquired immunologic response

Acquiredimmunologic response

Principal features:

Specific

Able to respond to innumerable stimuli

Able to distinguish self and non-self

Has memory


Immunology

Immunology:


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