Lecture 1. Amino acid s. Functions of amino acids. A variety of roles in metabolism the building blocks of proteins forming parts of coenzymes as precursors for the biosynthesis of molecules such as heme. Standard and nonstandard amino acids.
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(or R group, R=“Remainder of the molecule”)
2. Stereochemistry of amino acids
They are jointly responsible for the light absorption of proteins at 280 nm.
1. All 20 are -amino acids
2. For 19 of the 20, the -amino group is primary; for proline, it is secondary (imino acid)
3. Except glycine, the -carbonsfor 19 of them are asymmetric (orchiral).
Ala Val Leu Ile Gly Pro Phe Trp
Ser Thr Cys Asn Gln Met Tyr
Lys Arg His
Many additional nonstandard amino acids are found in cells, but not in proteins
Amino acid residue