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Short-Acting Intrathecal Opioids Fentanyl / Sufentanil

Short-Acting Intrathecal Opioids Fentanyl / Sufentanil. Improves intraoperative analgesia 1–4 ↓ Local anesthetic doses → ↓ hypotension 2,4 ↓ Intraoperative nausea and vomiting 3,4 ↓ Shivering RR = 0.26 4 ↑ Pruritus RR = 11.7 4 ; dose-related 3–5 M ay induce subtle acute tolerance 6

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Short-Acting Intrathecal Opioids Fentanyl / Sufentanil

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  1. Short-Acting Intrathecal Opioids Fentanyl / Sufentanil • Improves intraoperative analgesia1–4 • ↓ Local anesthetic doses →↓ hypotension2,4 • ↓ Intraoperative nausea and vomiting3,4 • ↓ Shivering RR = 0.264 • ↑ Pruritus RR = 11.74; dose-related3–5 May induce subtle acute tolerance6 Optimal fentanyl dose: 10–15 µg3,7 1. Dahlgren, Anesth Analg1997;85:1288-93 2. Ben-David, Reg Anesth Pain Med2000;25:235-9 3. Dahl, Anesthesiology1999;91:1919-27 4. Pöpping, Pain 2013;154(8):1383-90 5. Palmer, Reg Anesth1995;20:389-94 6. Carvalho, Int J Obstet Anesth2012;21:29-34 7. Hunt, Anesthesiology1989;71:535-40 Intraoperative Pain (% patients)1,3

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