slide1
Download
Skip this Video
Download Presentation
Self-assembly in Nature

Loading in 2 Seconds...

play fullscreen
1 / 17

Self-assembly in Nature - PowerPoint PPT Presentation


  • 69 Views
  • Uploaded on

Self-assembly in Nature. Nano. Self-assembly of amphiphilic molecules. spherical micelles. cylindrical micelles. nanotubes. vesicles (liposomes). Drug delivery systems. Direct conjugation of drugs or therapeutic proteins to macromolecules such as polymers and proteins.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' Self-assembly in Nature' - hila


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
slide4

spherical micelles

cylindrical

micelles

nanotubes

vesicles (liposomes)

slide6

Drug delivery systems

  • Direct conjugation of drugs or therapeutic proteins
  • to macromolecules such as polymers and proteins.
slide9

The enhanced permeability and retention (EPR) effect

Macromolecules cannot pass through the capillary walls of normal tissue. The entry of macromolecules into tumor tissue takes place in the capillaries where blood flow is diminished and nutrients transfer into the tissue. In contrast to the blood capillaries in most normal tissues, the endothelial layer of the capillaries in the tumor tissue is fenestrated and leaky so that macromolecules and other nanoparticles reach the malignant tissue. Tumor tissue generally has a defective lymphatic drainage system with the result that macromolecules are retained and can subsequently accumulate in solid tumors.

slide11

DLS

Release of Calcein

18nm

pH 5

pH 7

pH 7

3nm

pH 5

pH drop

1

10

100

Vesicle

d = 36 nm

Micelle

d = 6 nm

Radius (nm)

pH-Responsive Nanocapsules

HCl

J. Am. Chem. Soc. 2004,126, 12724

slide14

Antigen

Carbohydrate – Protein Multivalent Interactions

antigen

carbohydrate

Kiessling et. al. J. Am. Chem. Soc.2002, 124, 14922.

slide15

Mannose-Coated Supramolecules

lectinprotein

d= 40 nm

d= 20 nm

d= 10 nm

12

23

100 nm

100 nm

glycocluster

50 nm

Galactose

Micelle

Cylinder

Sphere

Vesicle

2

1

3

Hemagglutination Inhibition Assay

n.d.

J. Am. Chem. Soc.2005, 127,16333

Chem. Commun.2005, 2035

J. Am. Chem. Soc.2007, in press

slide16

Selective Binding of Supramolecules to Bacterial Cells

E. coli

E. coli

pili

Binding to

E. coli ORN 178

TEM

100 nm

100 nm

100 nm

E. Coli (ORN 208)

E. Coli (ORN 178) + cylinders

E. Coli (ORN 178) + spheres

slide17

=

=

D-mannose-binding protein

Selective-binding

+

Pathogen

Pathogen

ß-sheet assembly

Binding of Bacterial Cells

ad