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Hardy-Weinberg Rule

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Hardy-Weinberg Rule

Allele frequencies when populations are NOT evolving

- Allele frequencies will NOT change (stay in equilibrium) if the following conditions are met:
- No mutation
- Large population isolated from other populations of same species
- Random mating
- Individuals survive and reproduce equally

- When would we want to know this info?
- It provides a yardstick by which changes in allele frequency can be measured.
- You can see if a population is evolving

Formula for the allele frequency is

p2 + 2pq + q2 = 1

P2 is AA

pq is Aa ( x 2 because aA also)

q2 is aa

You can use the formula to track alleles from one generation to the next to see if the gene frequencies are changing.

p= frequency of allele A

q= frequency of allele a

p+ q = 1

- If you know the percent of homozygous recessive out of the total population, you know q2. Take the square root of it to find q. q is the frequency of a. Then you can find the rest.