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Dry Atmospheric Gas at Standard Barometric PressurePowerPoint Presentation

Dry Atmospheric Gas at Standard Barometric Pressure

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Dry Atmospheric Gas at Standard Barometric Pressure

- Po2 159.0 torr
- Pco2 0.3 torr
- PN2 600.6 torr

Inspired Gas at Standard Barometric Pressure

- PIo2 149.0 torr
- PIco2 0.3 torr
- PIN2 564.0 torr
- PIH2O 47.0 torr

Alveolar Gas at Standard Barometric Pressure

- PAo2 104.0 torr
- PAco2 40.0 torr
- PAN2 569.0 torr
- PAH2O 47.0 torr

Mixed Expired Air at Standard Barometric Pressure

- PEo2 120.0 torr
- PEco2 27.0 torr
- PEN2 566.0 torr
- PEH2O 47.0 torr

O2 Carrying Capacity of Hemoglobin

1 gram of hemoglobin can combine with 1.34ml of oxygen when fully saturated

Pco2 , pH

temp, BPG

100

80

Pco2 , pH

temp, BPG

60

Hemoglobin saturation, %

50%

40

20

20

40

60

80

100

120

140

160

P50

Partial pressure of oxygen, torr

CYANOSIS

- Occurs when more than 5 grams of hemoglobin/100 ml of arterial blood are in the “deoxy” state
- Absence of cyanosis does not rule out hypoxemia (anemia)
- Presence of cyanosis does not always indicate hypoxemia (polycythemia)

Solubility of CO2 in Plasma

At 37°C 1 ml of plasma contains 0.03 mmol of CO2 / torr Pco2

Or

0.0006 ml of CO2 / torr Pco2

Transport of CO2 by the Blood

CO2

(Gas phase)

Carbonic

Anhydrase

_

CO2 + H2O

H2CO3

H+ + HCO3

(Dissolved in the aqueous phase)

PLASMA

ERYTHROCYTE

CO2

CO2

dissolved

CO2

H2O +

CO2

H2O

CO2

Carbonic anhydrase

dissolved

H2CO3

Cl-

Cl-

CAPILLARY WALL

HCO3-

HCO3- + H+

H+ + HbO2

O2

O2

O2 + HHb

HHb+CO2

O2

Carbamino compounds

PLASMA

ERYTHROCYTE

CO2

CO2

dissolved

CO2

H2O +

CO2

H2O

CO2

Carbonic anhydrase

dissolved

H2CO3

Cl-

Cl-

CAPILLARY WALL

HCO3-

HCO3- + H+

H+ + HbO2

O2

O2

O2 + HHb

HHb+CO2

O2

Carbamino compounds

Pvo2

Cvo2

A Classification of the Causes of Hypoxia

Increased

FIo2

helpful?

PAo2

Pao2

Cao2

Classification

Hypoxic hypoxia

Low alveolar Po2

Diffusion impairment

Right to left shunts

V/Q mismatch

Anemic hypoxia

CO poisoning

Hypoperfusion hypoxia

Histotoxic hypoxia

Low

Norm

Norm

Norm

Norm

Norm

Norm

Norm

Low

Low

Low

Low

Norm

Norm

Norm

Norm

Low

Low

Low

Low

Low

Low

Norm

Norm

Low

Low

Low

Low

Low

Low

Low

High

Low

Low

Low

Low

Low

Low

Low

High

Yes

Yes

No

Yes

No

Possibly

No

No

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