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Cell Injury and the Pathogenesis of Human Disease (PATH 6266 )

Cell Injury and the Pathogenesis of Human Disease (PATH 6266 ). April 30 and May 2 , 2012 Paul Boor M.D. “Cellular basis of disease” 200 years of observation : organ and microscopic. SUGGESTED READING (PATHOLOGIC BASIS OF DISEASE, 8 th EDITION)

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Cell Injury and the Pathogenesis of Human Disease (PATH 6266 )

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  1. Cell Injury and the Pathogenesis of Human Disease(PATH 6266) April 30 and May 2, 2012 Paul Boor M.D. “Cellular basis of disease” 200 years of observation: organ and microscopic

  2. SUGGESTED READING(PATHOLOGIC BASIS OF DISEASE, 8th EDITION) CHAPTER 1Cellular Response to Stress and Toxic Insult; Adaptation, Injury, Death (pp 3-42) CHAPTER 3Tissue Renewal, Repair, and Regeneration (pp 79-110)

  3. Rudolph Virchow (1821-1902)Cell Theory“Social Medicine”

  4. Cell Injury – General Considerations • Numerous causes • Biochemical events precede structural • Duration and intensity of exposure important (direct dose/response relationship) • Injury may be TISSUE (or cell) specific • Injury depends of ability of cells to respond, resist, and repair injury

  5. Cell Injury – Causes • Hypoxia / Ischemia • Physical (mechanical, heat, radiation) • Chemical • Biologic Agents • Immunologic (host) reaction • Genetic derangement • Nutritional imbalance, deficiency

  6. Cellular Degeneration Sublethal, usually reversible forms of cellular injury unassociated with severe cellular dysfunction.

  7. Oxidative Stress and Cell Injury

  8. Necrosis (or “Oncosis”) VSApoptosis

  9. Types of Necrosis • Coagulation • Liquefactive • Caseous • “Fat” necrosis

  10. Liquefactive Necrosis

  11. Caseous Necrosis

  12. “Fat” Necrosis

  13. Key Words(Week 1 BBSC 6266) • Anatomy of the hepatic lobule; • Cell: Hepatocyte, Kupffer cell, bile ductules; • Acetaminophen; • Cytochrome p450s; imines; • Reactive oxygen species; reactive nitrogen species; peroxynitrite; • Adducts

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