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DNA Structures

DNA Structures. September 19, 21 2006. Canonical DNA structures. B DNA. B DNA View down helix axis. Space filling B DNA. Defined sequence DNA CGCGAATTCGCG. High propeller in center Narrow minor groove. Spine of hydration. A DNA. Right handed Bases tilted Deep major groove. A DNA.

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DNA Structures

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  1. DNA Structures September 19, 21 2006

  2. Canonical DNA structures

  3. B DNA

  4. B DNA View down helix axis

  5. Space filling B DNA

  6. Defined sequence DNA CGCGAATTCGCG • High propeller in center • Narrow minor groove

  7. Spine of hydration

  8. A DNA • Right handed • Bases tilted • Deep major groove

  9. A DNA

  10. Defined sequence A DNA

  11. Z DNA-2 nucleotide repeat

  12. Z DNA • Left handed • Very deep minor groove • Major groove on outside Voet, Donald and Judith G. Biochemistry. John Wiley & Sons, 1990, p. 802.

  13. Defined sequence CGCGCG

  14. Mismatches • Local changes • Global structure same as parent

  15. PNA Triple strand • DNA strand + Peptide nucleic acid sequence

  16. Quadruplex DNA

  17. G pairing in quadruplex

  18. Diversity of folds • Two different dimer folds • Also possible • Single strand • Four strands

  19. Holliday junction formed by 4 decamer strands

  20. 4 way junction

  21. RNA-DNA complex with a junction structure

  22. References Neidle, Stephen. Nucleic Acid Structure and Recognition. Oxford University Press, 2002, pp. 33-36, 76-77, 83, 97. Voet, Donald and Judith G. Biochemistry. John Wiley & Sons, 1990, pp. 796, 799, 800, 802.

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