Pharmacoepidemiology
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Pharmacoepidemiology. Huang, Boji. Pharmacoepidemiology is the study of the use of the effects of drugs in large numbers of people. The term pharmacoepidemiology contains two components: "pharmaco" and "epidemiology.".

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Pharmacoepidemiology

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Pharmacoepidemiology

Pharmacoepidemiology

Huang, Boji


Pharmacoepidemiology

Pharmacoepidemiology is the study of the use of the effects of drugs in large numbers of people. The term pharmacoepidemiology contains two components: "pharmaco" and "epidemiology."


Pharmacoepidemiology

The joining of the fields of clinical pharmacology and epidemiology has resulted in the development of a new field: pharmacoepidemiology, the study of the use of and the effects of drugs in large numbers of people.


Pharmacoepidemiology

Pharmacoepidemiology applies the methods of epidemiology to the content area of clinical pharmacology.


Pharmacoepidemiology

Pharmacoepidemiology encompasses elements of both of these fields, exploring the effects achieved by administering a drug regimen. It does not normally involve or require the measurement of drug levels.


Pharmacoepidemiology

Pharmacoepidemiology has become the science underlying postmarketing drug surveillance, studies of drug effects which are performed after a drug has been marketed.


Pharmacoepidemiology

In attempting to optimize the use of drugs, one central principle of clinical pharmacology is that therapy should be individualized, or tailored to the needs of the specific patient at hand.


Pharmacoepidemiology

Clinical pharmacology is traditionally divided into two basic areas, pharmacokinetics and pharmacodynamics.


Pharmacoepidemiology

Together, these two fields allow one to predict the effect one might observe in a patient from administering a certain drug regimen.


Pharmacoepidemiology

Specifically, the field of pharmacoepidemiology has primarily concerned itself with the study of adverse drug effects including Type A and Type B reactions.


Pharmacoepidemiology

The usual approach to studying adverse drug reactions has been the collection of spontaneous reports of drug-related morbidity or mortality.


Pharmacoepidemiology

However, determining causation in case reports of adverse reactions can be problematic, as can attempts to compare the effects of drugs in the same class.


Pharmacoepidemiology

This has led academic investigators, industry, FDA, and the legal community to turn to the field of epidemiology.


Pharmacoepidemiology

Specifically, studies of adverse effects have been supplemented with studies of adverse events.


Pharmacoepidemiology

This marriage of the fields of clinical pharmacology and epidemiology has resulted in the development of a new field: pharmacoepidemiology.


Pharmacoepidemiology

Since pharmacoepidemiology is the study of the use of and effects of drugs in large numbers of people, it falls within epidemiology, as well. Epidemiology is also traditionally subdivided into two basic areas.


Pharmacoepidemiology

The pharmacoepidemiology field uses the techniques of chronic disease epidemiology to study the use of and the effects of drugs.


Pharmacoepidemiology

Although pharmacoepidemiology method application can be useful in performing the clinical trials of drugs which are performed prior to marketing, the major application of these principles is after drug marketing.


Pharmacoepidemiology

This has primarily been in the context of post-marketing drug surveillance, although in recent years the interests of pharmacoepidemiologists have broadened.


Pharmacoepidemiology

Thus, pharmacoepidemiology is a relatively new applied field, bridging between clinical pharmacology and epidemiology.


Pharmacoepidemiology

From clinical pharmacology, pharmacoepidemiology borrows its focus of inquiry. From epidemiology, pharmacoepidemiology borrows its methods of inquiry.


Pharmacoepidemiology

In other words, it applies the methods of epidemiology to the content area of clinical pharmacology.


Pharmacoepidemiology

In the process, multiple special logistical approaches have been developed and multiple special methodological issues have arisen.


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