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FRAC Mode of Action Expert Panel. DH / July 2012. Background. The annually updated list of fungicides according to mode of action (MoA) is a key document provided by FRAC (#1 accessed on www.frac.info)

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FRAC Mode of Action Expert Panel

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Frac mode of action expert panel

FRAC Mode of Action Expert Panel

DH / July 2012


Background

Background

  • The annually updated list of fungicides according to mode of action (MoA) is a key document provided by FRAC (#1 accessed on www.frac.info)

  • In order to ensure consolidated input on classification for new inclusions to the list or on changes in mode of action classification across the companies involved in the FRAC Steering committee, it was decided in Dec 2011 to establish a MoA expert panel consisting of nominated key scientists.


Purpose accountabilities ways of working of the frac moa expert panel

Purpose, accountabilities, ways of working of the FRAC MoA Expert Panel

The panel advices the Steering Committee on all matters relating to the mode of action of antifungal agents considered by FRAC and is responsible for the technical content of the FRAC MoA Code List and associated publications.

  • Scientific evaluation of information on mode of action provided by manufacturers to support classification of new inclusions to the code list or to revise current classification in case of new evidence provided

  • Liase with manufacturers, licensees or other responsible organizations in order to agree the mode of action of new agents as appropriate

  • Review new literature to pro-actively challenge current classification in the list or to propose classification of compounds listed as of unknown mode of action

    The panel works like an expert forum without regular face to face meetings, by sharing expert opinions on shared documents.

    The agreed judgements of the panel is consolidated by the chairperson of the panel and shared with the Steering commitee. The Chairperson is appointed member of the FRAC Steering committee.


Membership of the frac moa expert panel

Membershipof the FRAC MoA Expert Panel

The Chair of the panel is elected by the FRAC Steering committee and is from the R&D driven agricultural industry. The chairperson is appointed member of the Steering committee.

Members of the panel are nominated by the steering committee members within their R&D functions and by the chairperson of the panel. Decision on membership is by the FRAC Steering committee.

Members are recognized experts in the field; they usually, but not necessarily are from the industry

Current membership:

  • Dietrich Hermann, Syngenta – Chair

  • Andy Corran / Gabriel Scalliet, Syngenta – Experts

  • Helmut Schiffer, BASF – Expert

  • James Sweigard, DuPont – Expert

  • Klaus Tietjen, Bayer – Expert

  • David Young, Dow – Expert


Single slide version for presentations

Single Slide Version for presentations


Frac mode of action panel

FRAC Mode of Action Panel

  • Founded in 2012 to support the FRAC steering committee on matters relating the scientific evaluation of matters related to inclusion or changes of antifungal agents on the FRAC Mode of Action code list and related publications

  • Key objectives are:

    • Scientific evaluation of information on mode of action provided by manufacturers

    • Liase with manufacturers, licensees or other responsible organizations in order to agree the mode of action of new agents

    • Review new literature to pro-actively challenge current classification in the list (we are open for external inputs)

  • The panel operates without face to face meetings and is represented by the chairperson on the FRAC steering committee

  • Current membership:

    • Members are typically recognizedexperts in the field of mode of action

    • Nominated by members of the FRAC SC within their companies

    • Could also be non industry experts


Frac code list

FRAC Code List

DH / 11.12.12


Open actions on ai s from previous meetings

Open Actions on AI‘s from previous meetings

Pyrimorph

  • should be included with the CAA molecules (H5). Action Michael Merck

  • Answer from China received on Dec 6th, 2012:

    Mr. Yang,Very pleased to receive your letter. About pyrimorph mechanism, we have done a lot of work, from the perspective of the receptor and also from the resistance mechanisms. Results from the present study showed that it either can affect the synthesis of the cell wall, but also affect the respiratory chain (complex III), so it should be a complex mechanism, but the latter is relatively weak (but stronger than fimethomorph and flumorph). Therefore, I agree to included pyrimorph in the H5 group.Best wishes!Tan Zhaohai

    Proposal: Include to 2013 update with CAA, H5

Dec 2012, D. Hermann

FRAC SC Meeting


Open actions on ai s from previous meetings1

Open Actions on AI‘s from previous meetings

Ametoctradin

  • Currently C8 QxI

  • French officials have listed it with QiI (C4)

  • Ongoing action for KK/RG to resolve with French officials

  • Status?


Open actions on ai s from previous meetings2

Open Actions on AI‘s from previous meetings

Ethaboxam

  • Now Sumitomo (previously LG) . Classified as U5. Proposal by FRAC SC to reclassify to B3 with Zoxamide.

  • Valent supportive.

  • Sumitomo agreement received in November:

    B: mitosis and cell divisionTARGET SITE AND CODE: B3: ß-tubulin assembly in mitosis

    GROUP NAME: thiazole carboxamide

    CHEMICAL GROUP: ethylamino-thiazole carboxamide FRAC CODE: 22

  • Proposal: reclassify from U5 to B3 in 2013 update

Dec 2012, D. Hermann

FRAC SC Meeting


Tolfenpyrad inclusion to c1 agreed in may 12 meeting

Tolfenpyrad inclusion to C1 Agreed in May 12 meeting

  • In our May meeting we supported the request for inclusion of Tolfenpyrad from Nihon Nohyaku into C1 (complex 1 respiration) based on the following information:

    1. Label inclusion

    several diseases in the product label in Japan:

    Powdery mildew : cucumber, watermelon, tomatoes, peas and eggplant

    Rust : Green onion

    White rust (Albugo) : Japanese radish, turnip and chrysanthemum

    2. Recognition in practical usage – pesticide program in green onion (Japanese) listing tolfenpyrad for pest control and against rust 

  • Agreed by the Moa expert panel.

  • NN informed by me, they appreciate our decision.

  • Include to C1 on 2013 list

FRAC SC Meeting


Frac mode of action expert panel

Requests for inclusion to code list by Japan FRAC

Fluoromide(Nihon Noyaku)

Mainly used on apple and tea as protective fungicide.

Chinomethionat (AgroKanesho)

Widely used to control powdery mildew on vegetables and fruit trees, etc.

Ask for MoA & chemistry grouping info. Share with Expert panel for feedback

Feedback received from both companies in November, circulated with expert forum, agreement to classify as multisite fungicides

Proposal: Include both compounds to M in 2013 update

FRAC SC Meeting


Fluoroimide

Fluoroimide

Nihon Nohyaku provided an article on MoA from 1976 and the classification proposal

FRAC SC Meeting


Chinomethionat

Chinomethionat

Feedback AgroKanesho:

An S-H inhibitor (Thiol reactive).

Agreed by MoA Expert Panel

FRAC SC Meeting


Fenpyrazamine sumitomo

Fenpyrazamine - Sumitomo

  • Proposed for inclusion in 2011, but rejected by Sumitomo

  • Presented in Italy and Germany at conferences in 2012, remarks on similarity of MoA to Fenhexamid

  • Bayer (Klaus Tietjen) confirms similar MoA results for both compounds:

    We have now critically reviewed our results and are convinced, that Fenpyrazamine shares the mode of action with Fenhexamid:

    Fenpyrazamine changes the spectrum of sterols in Botrytis culture in the same way as Fenhexamid and in a way consistent with inhibition of sterol 3-ketoreductase.

    Fungal isolates are cross-resistant to Fenpyrazamine and Fenhexamid.

  • In November, Sumitomo agreed and proposes classification as follows:

    G: sterol biosynthesis in membranes

    TARGET SITE AND CODE: G3:3-keto reductase

    GROUP NAME: pyrazolinone (SBI: Class III)

    CHEMICAL GROUP: amino-pyrazolinone

    FRAC CODE: 17

Proposal: Include to 2013 update as proposed by Sumitomo

FRAC SC Meeting


Tebufloquin meiji seika

Tebufloquin – Meiji Seika

  • Proposed for inclusion 2011, but rejected by Meiji Seika

  • Approached again this automn, but mails no more delivered to to company restructuring

  • New contact established through JFRAC

  • Now answer received so far


New pending iso approvals

New (pending) ISO approvals

  • Isofetamid, Ishihara IKF 5411: SDHI – contact details provided by JFRAC, approached ISK in early November, reply Dec 10!

  • Tolprocarb, Mitsui MTF 0301 Rice blast – answer: wait another year

  • Oxathiapiprolin, DuPont DPX-QGU42- wait for 2014 list, plan to present at Reinhardsbrunn

1

2

3

FRAC SC Meeting


Isofetamid

Isofetamid

Answer by ISK Dec 10:

Dear Dr. Dietrich Hermann

In response to your e-mail, we propose isofetamid is SDHI and should be added in category C2.

We found that isofetamid exhibited no cross resistance to boscalid and other carboximide fungicides. We conducted several experiments for the possible development of resistance to isofetamid including field monitoring studies and mutation studies to generate resistant mutant in the laboratory. Based on the studies, no evidence of resistance build up risk was found.

In this regard, we think it would not fit current rating “medium to high resistance risk” to isofetamid.

Shigeru Mitani (Dr.) Fungicide Group Leader

  • Include to C2 in 2013 list?

  • Action for SDHI Working group to agree on wording?


Fenaminostrobin fenaminstrobin

Fenaminostrobin -> Fenaminstrobin

Iso name was reviewed and now Fenaminstrobin is approved for this C3 QoI compound from Shenyang


Bacillus subtilis var amyloliquefaciens mbi600 inclusion

Bacillus subtilis var amyloliquefaciensMBI600 inclusion

  • First request for inclusion via FRAG-UK in March.

  • Asked Andrew Brown, Becker Underwood Ltd. for more information

  • Detailed information was received in November

  • Agreement by Expert Panel this is very good quality information

  • Proposal: Include to F6 /44 as third product, same text as for B subtilis QST713 – for 2013 update

FRAC SC Meeting


Frac mode of action expert panel

Bacillus subtilis var amyloliquefaciens strain Ba D747 «Double Nickel» Certis USA, licensed from Kumiai («Ecoshot»)

  • Certis approached me during the APS meeting and provided labels and a press release in August

  • Some mail follow-up, but no further Mode of Action information provided

  • EPA approved December 2011

    Proposal: include to Code 44 as other BSA strains


How to list biologicals

How to list biologicals

  • Feedback from the MoA Expert panel is that a seperate category for biologicals would be preferred , with subgroups by predominant/most likely Mode of Action.

  • Agreement that we need to work on a proposal, but stay with current approach for 2013 update


Isagro sdhi

Isagro SDHI

AgreWorld Daily Note - 24 September 2012

Isagro and FMC in R&D Collaboration

Isagro has entered into a research and development collaboration with FMC for a new proprietary fungicide active ingredient which was discovered by the company’s IsagroRicerca subsidiary. Under the terms of the agreement, the two companies will co-develop the carboxamide fungicide product for worldwide use.


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