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Role of Research in the Field of UTI -Past, Present and Future- (from my Personal History)

Role of Research in the Field of UTI -Past, Present and Future- (from my Personal History). Joichi Kumazawa. My history. 1: Postgraduate School (1960-1964) 2: Dept. of Urology, Kyushu University (The first term) (1964-1969) 3: Harvard Medical School (1969-1970)

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Role of Research in the Field of UTI -Past, Present and Future- (from my Personal History)

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  1. Role of Research in the Field of UTI -Past, Present and Future- (from my Personal History) Joichi Kumazawa

  2. My history 1: Postgraduate School (1960-1964) 2: Dept. of Urology, Kyushu University (The first term) (1964-1969) 3: Harvard Medical School (1969-1970) 4: Dept. of Urology, Kyushu University (The second term) (1970- 1979) 5: Dept. of Urology, Saga Medical College (1979-1984) 6: Dept. of Urology, Kyushu University (The third term) (1984-1998) 7: After the retirement from Kyushu University (1998-present)

  3. 1: Postgraduate school (1960-1964) (Dept. of Bacteriology and Dept. of Urology) # Chronological change of urinary isolates Method of urine collection Quantitative culture of urine: Surface spreading method Antimicrobial susceptibility test of urinary isolates # Pathogenesis of urinary isolates: Immunological research (Serum antibody detection by hemagglutination in UTI patients) # Annual meeting of JUA: First symposium on UTIs (Tokyo, 1962) # UTIs in children

  4. 非特異性尿路感染症に関する研究 • 第1報　尿路分離菌の年次的変遷について • 大学院生　熊澤淨一 • 九州大学医学部泌尿器科教室（主任　富川梁次教授） • Studies of non-Specific Urinary Tract Infection. • I. Chronological changes of Bacteria Isolated in Urinary • Tract Infection. • Zyoichi KUMAZAWA M.D • Department of Urology (Director: Prof. Dr. R. Tomikawa), Faculty of Medicine, • Kyushu University, Fukuoka, Japan • 福岡医学雑誌第54巻第10号（昭和38年11月25日） • FUKUOKA ACTA MEDICA, 54(10):1072-1083,1962

  5. Number of bacteria in first-catch urine (VB1), mid-stream urine (VB2) and urine by catheter-collection

  6. Number of bacteria in urine in patients with or without UTI

  7. 1: Postgraduate school (1960-1964) Dept. of Bacteriology and Dept. of Urology # Chronological change of urinary isolates Method of urine collection Quantitative culture of urine: Surface spreading method Antimicrobial susceptibility test of urinary isolates # Pathogenesis of urinary isolates: Immunological research (Serum antibody detection by hemagglutination in UTI patients) # Annual meeting of JUA: First symposium on UTIs [Tokyo, 1962] # UTIs in children

  8. 非特異性尿路感染症に関する研究 • 第2報　尿路分離菌の病原性に関する免疫学的研究 • 大学院生　熊澤淨一 • 九州大学医学部泌尿器科教室（主任　富川梁次教授） • Studies of non-Specific Urinary Tract Infection. • I. Immunological Determination on Pathogenicity of Bacteria Isolated in Urinary Tract Infection. • Zyoichi KUMAZAWA M.D • Department of Urology (Director: Prof. Dr. R. Tomikawa), Faculty of Medicine, • Kyushu University, Fukuoka, Japan • 福岡医学雑誌第54巻第10号（昭和38年11月25日） • FUKUOKA ACTA MEDICA, 54(10):1084-1103,1963

  9. Antibody titers in 22 patients with >105/ml of bacteriuria during >7 days Bacterial species Escherichia coli Pseudomonas aeruginosa Proteus spp Staphylococcus spp Klebsiella spp Enterobacter aerogenes Total Antibody titer >160 <160 5 1 4 2 1 1 2 2 1 3 17 (77.3%) 5 (22.7%)

  10. 1: Postgraduate school (1960-1964) Dept. of Bacteriology and Dept. of Urology # Chronological change of urinary isolates Method of urine collection Quantitative culture of urine: Surface spreading method Antimicrobial susceptibility test of urinary isolates # Pathogenesis of urinary isolates: Immunological research (Serum antibody detection by hemagglutination in UTI patients) # Annual meeting of JUA: First symposium on UTIs [Tokyo, 1962] # UTIs in children

  11. 小児泌尿器疾患の統計的観察 • S. Sakamoto, J. Kumazawa and M. Ishizu • Statistical Observation of Urogenital Diseases in Children • 九州大学医学部泌尿器科教室（主任　富川梁次教授） • 坂本公孝 • 熊澤淨一 • 石津又三 • 皮膚と泌尿 • （昭和39年2月発行） • HIFU to HINYO 26(1):43-48,1964

  12. UTIs in pediatric outpatients Incidence (%) 46.9 (98.1) 17.2 66.6 54.2 53.0 66.6 8.0 1.1 15.1 Basic diseases Uncomplicated UTIs (Hemorrhagic cystitis) Inflammation of genital region Urinary Stone Congenital urinary obstruction Neurogenic bladder Urinary tumor Nephritis or nephrosis Others Total Number 143 (53) 29 21 24 17 9 25 538 806 Infection 67 (52) 5 14 13 9 6 2 6 122

  13. 2: Dept. of Urology, Kyushu University (The first term) (1964-1969) # Experimental pyelonephritis # VUR in children # Publish: 「尿路感染症の臨床：Clinical aspect of UTIs」(1965) # Chronological changes in urinary isolates # Detection of fallen bacteria in the hospital: Pseudomonas aeruginosa

  14. 実験的腎盂腎炎に対するEnduracidinの効果 • Effect of Enduracidin on Experimental Pyelonephritis • S. Momose, J. Kumazawa, S. Narahashi, S. Hidaka • CHEMOTHERAPY 16(4):466-469,1968 • 百瀬俊郎 • 熊澤淨一 • 楢橋勝利 • 日高正昭 • 九州大学医学部泌尿器科

  15. Experimental method

  16. 2: Dept. of Urology, Kyushu University (The first term) (1964-1969) # Experimental pyelonephritis # VUR in children # 「尿路感染症の臨床：Clinical aspect of UTIs」published (1965) # Chronological changes in urinary isolates # Detection of fallen bacteria in the hospital: Pseudomonas aeruginosa

  17. いわゆる萎縮腎型腎盂腎炎に関する２，３の考察いわゆる萎縮腎型腎盂腎炎に関する２，３の考察 • Some Aspects on So-called Atrophic Pyelonephritis • K. Sakamoto, J. Kumazawa, K. Narahashi • From Department of Urology, Faculty of Medicine, Kyushu University (Director: Prof. Dr. S. Momose) • 泌尿器科紀要　第12巻第1号 • Acta Urologica Japonica 12(1):71-77,1966

  18. VUR in patients with chronic UTIs Generation Children Adults Total VUR 5 5 10 Incidence (%) 62.5 22.7 33.3 Number 8 22 30

  19. Clinical aspect of UTIs published in 1965

  20. 3: Harvard Medical School (1969-1970) # Experimental pyelonephritis # Quantitative culture of bacteria in urine (Dip Slide Method)

  21. 基疾患を伴う実験的腎盂腎炎に対する化学療法の効果基疾患を伴う実験的腎盂腎炎に対する化学療法の効果 • The effect of Chemotherapy for the Experimental Pyelonephritis with Some Underlying Course • J. Kumazawa • Department of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyushu University, Fukuoka, Japan • Channing Laboratory (Director: Prof. Edward H. Kass), Department of Medicine, Harvard Medical School, Boston. Mass., USA • 熊澤淨一 • 九州大学医学部泌尿器科（主任：百瀬俊郎） • 西日本泌尿器科　第33巻第2号 • Nishinihon J. Urol. 33(2):183-189,1971

  22. 簡易尿中細菌定量培養法 • Evaluation of Simplified Quantitative Culture Methods of Urinary Bacteria • J. Kumazawa, S. Nakamuta, H. Ito, S. Hieda • Department of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyushu University, Fukuoka, Japan • 熊澤淨一、中牟田誠一、伊藤秀明、稗田定 • 九州大学医学部泌尿器科（主任：百瀬俊郎） • 西日本泌尿器科　第38巻第4号 • Nishinihon J. Urol. 38(4):477-487,1976

  23. 4: Dept. of Urology, Kyushu University (The second term) (1970 -1979) # Anaerobic bacteria # Clinical evaluation of drug efficacy in UTIs Kyushu University Criteria (1970) Japanese Criteria (1976) (Establishment of Japanese Research Association on UTIs) # UTIs in children: VUR # Nosocomial infection Pseudomonas aeruginosa Closed drainage system # Chronological change of urinary isolates

  24. Significance of Anaerobic Bacteria Isolated from the Urinary Tract • I. Clinical studies • J. Kumazawa, H. Kiyohara, K. Narahashi, M. Hidaka, S. Momose • From the Department of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyushu University, Fukuoka, Japan • J. Urol 112:257-260,1974

  25. Significance of Anaerobic Bacteria Isolated from the Urinary Tract • II. Experimental studies • J. Kumazawa, H. Kiyohara, S. Momose • From the Department of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyushu University, Fukuoka, Japan • Invest. Urol. 13:309-312,1975

  26. 4: Dept. of Urology, Kyushu University (The second term) (1970 -1979) # Anaerobic bacteria # Clinical evaluation of drug efficacy in UTIs Kyushu University Criteria (1970) Japanese Criteria (1976) (Establishment of Japanese Research Association on UTIs) # UTIs in children: VUR # Nosocomial infection Pseudomonas aeruginosa Closed drainage system # Chronological change of urinary isolates

  27. Clinical Effectiveness of Piromidic Acid (PA) on Acute Nonspecific Cystitis. • Evaluation with Double Blind Method • J. Kumazawa, S. Momose et al • Department of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyushu University, Fukuoka, Japan • Chemotherapy 19(5):657-664,1971

  28. A Double Blind Controlled Study to Compare CS-1170 (Cefmetazole) and Cefazolin in the Treatment of Chronic Complicated Urinary Tract Infections • S. Momose, J. Kumazawa, et al • Department of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyushu University, Fukuoka, Japan • Nishinihon J. Urol. 41(1):173-200,1979

  29. UTI薬効評価基準 • Criteria for Evaluation of Clinical Efficacy of Antimicrobial Agents on Urinary Tract Infection • （第4版暫定案） • 1996年12月5日

  30. 4: Dept. of Urology, Kyushu University (The second term) (1970 -1979) # Anaerobic bacteria # Clinical evaluation of drug efficacy in UTIs Kyushu University Criteria (1970) Japanese Criteria (1976) (Establishment of Japanese Research Association on UTIs) # UTIs in children: VUR # Nosocomial infection Pseudomonas aeruginosa Closed drainage system # Chronological change of urinary isolates

  31. 小児尿路感染症-現況と治療の問題点- • Urinary Tract Infection in Childhood • J. Kumazawa • Department of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyushu University, Fukuoka, Japan • 熊澤淨一 • 九州大学医学部泌尿器科（主任：百瀬俊郎） • 西日本泌尿器科　第35巻第2号 • Nishinihon J. Urol. 35(2):144-152,1973

  32. VUR and Pyelonephritis J. Kumazawa Associate Professor, Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan Proceedings of The First Asian Pacific Congress of Nephrology p 94-97, 1979

  33. 4: Dept. of Urology, Kyushu University (The second term) (1970 -1979) # Anaerobic bacteria # Clinical evaluation of drug efficacy in UTIs Kyushu University Criteria (1970) Japanese Criteria (1976) (Establishment of Japanese Research Association on UTIs) # UTIs in children: VUR # Nosocomial infection Pseudomonas aeruginosa Closed drainage system # Chronological change of urinary isolates

  34. 泌尿器科的手技と病院感染 • ー緑膿菌感染を中心にー • Pseudomonas aeruginosa: Hospital Infection in Urological Field • J. Kumazawa, S. Nakamuta, H. Ito, S. Momose • Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan • 熊澤淨一,中牟田誠一、伊藤秀明、百瀬俊郎 • 九州大学医学部泌尿器科 • 最新医学　第30巻第3号 • Saishin Igaku 30(3):402-407,1975

  35. Closed drainage system（閉鎖式持続導尿装置）の使用経験 • A Clinical Application of Closed Urinary Drainage System • J. Kumazawa, S Nakamuta, S. Momose • Department of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyushu University, Fukuoka, Japan • 熊澤淨一,中牟田誠一、百瀬俊郎 • 九州大学医学部泌尿器科（主任：百瀬俊郎） • 西日本泌尿器科　第38巻第5号 • Nishinihon J. Urol. 38(5):660-668,1976

  36. 5: Dept. of Urology, Saga Medical College (1979-1984) # Development of New Antimicrobial agents: A Person in Charge of Clinical trials Fluoroquinolones, Cephems, Aminoglycosides etc # Enterococcus spp # Establishment of STD Research Group in Fukuoka and Saga (1984)

  37. 6: Dept. of Urology, Kyushu University (The third term) (1984-1998) # UTI Research Group in the Dept. of Urology, Kyushu University Leader; Dr Tetsuro Matsumoto Sub-leader; Dr Masatoshi Tanaka Molecular biological approach in the basic and clinical research on UTIs Bacterial pili, Adherence, Superoxide, Renal scarring (VUR) # UTIs in the elderly # STDs # Infection control

  38. Increases renal scarring by bacteria with mannose-sensitive pili T. Matsumoto, Y. Mizunoe, N. Sakamoto, M. Tanaka, J. Kumazawa Department of Urology, Faculty of Medeicine, Kyushu University Urol. Res. 18:299-303,1990

  39. Role of superoxide in renal scarring following infection by mannose-sensitve piliated bacteria T. Matsumoto, Y. Mizunoe, N. Ogata, M. Tanaka, J. Kumazawa Department of Urology, Faculty of Medicine, Kyushu University Urol. Res. 19:229-233,1991

  40. 分子生物学的アプローチによる尿路感染症の解析分子生物学的アプローチによる尿路感染症の解析 Molecular Biological Approach in the Research of UTIs 九州大学医学部泌尿器科 熊澤淨一 Joichi Kumazawa Department of Urology, Faculty of Medicine, Kyushu University 日本泌尿器科学会雑誌第85巻第1号 Jap. J. Urol. 85(1):14-18,1994

  41. 6: Dept. of Urology, Kyushu University (The third term) (1984-1998) # UTI Research Group in the Dept. of Urology, Kyushu University Leader; Tetsuro Matsumoto Sub-leader; Masatoshi Tanaka Molecular biological approach in the basic and clinical research on UTIs Bacterial pili, Adherence, Superoxide, Renal scarring (VUR) # UTIs in the elderly # STDs # Infection control

  42. Urinary Tract Infection in Geriatric Patients T. Matsumoto, J. Kumazawa Department of Urology, School of Medicine, University of Occupational and Environmental Health Department of Urology, Faculty of Medicine, Kyushu University Int. J. Antimicrob. Agents 11:269-273,1999

  43. 6: Dept. of Urology, Kyushu University (The third term) (1984-1998) # UTI Research Group in the Dept. of Urology, Kyushu University Leader; Tetsuro Matsumoto Sub-leader; Masatoshi Tanaka Molecular biological approach in the basic and clinical research on UTIs Bacterial pili, Adherence, Superoxide, Renal scarring (VUR) # UTIs in the elderly # STDs # Infection control

  44. Emergence of In Vitro Resistance to Fluoroquinolones in Neisseria gonorrhoeae Isolated in Japan M. Tanaka, T. Matsumoto, I. Kobayashi, U.Uchino, J. Kumazawa Department of Urology, Faculty of Medicine, Kyushu University Antimicrob. Agents Chemother. 39:2367-2370,1995

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