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Doc. Dr Zvezdana Kojić Decembar 2004.

Biolo ški mehanizmi regulacija - Fiziologija kardiovaskularnog sistema -. Aterogeneza: značaj lipidskih poremećaja i oksidativnog stresa. Novi faktori rizika za ishemijsku bolest srca. Doc. Dr Zvezdana Kojić Decembar 2004. Atherosclerosis: a multifactorial disease.

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Doc. Dr Zvezdana Kojić Decembar 2004.

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  1. Biološki mehanizmi regulacija - Fiziologija kardiovaskularnog sistema - Aterogeneza: značaj lipidskih poremećaja i oksidativnog stresa.Novi faktori rizika za ishemijsku bolest srca Doc. Dr Zvezdana Kojić Decembar 2004.

  2. Atherosclerosis:a multifactorial disease

  3. Arterial wall:structure and function

  4. Different stages of atherosclerotic plaquedevelopment

  5. Vascular endothelium modificationin atherosclerosis

  6. Plaque formation1 — Fatty streak

  7. Plaque formation2 — Fibrous cap

  8. Plaque formation3 — Lipid core

  9. Lipid core constitutionActivated macrophages accumulate lipids

  10. Lipid core constitutionLDL oxidation

  11. Parietal vascular inflammationThe activated macrophage produces inflammatory cytokines

  12. From plaque to thrombosis, key event: plaque rupture

  13. Plaque vulnerabilityKey role of macrophages

  14. Vulnerable plaqueKey role of the macrophage in vascular wall inflammation

  15. Fibrinogen is an independent risk factorfor atherosclerosis

  16. Vulnerable plaqueKey role of the macrophage in the degradation of the fibrous cap

  17. Tissue factor: the initiator of coagulation and thrombogenesis in vivo

  18. Tobacco and atherosclerosis

  19. Dyslipidemia and atherosclerosis

  20. Novi faktori rizika • ADMA ? • homocistein • grelin, leptin • mokraćna kiselina • Mg++, Fe++, Zn++, Cu++

  21. Literatura • Li AS., Glass CK. PPAR and LXR-dependent pathways controlling lipid metabolism and development of atherosclerosis. J Lip Res., 2004, 45(12): 2161-73. • Francois M, Kojda G. Effect of hypercholesterolemia and of oxidative stress on the nitric oxide-cGMP pathway. Neurochem Int. 2004 Nov;45(6):955-61. • Bursill CA, Choudhury RP, Ali Z, Greaves DR, Channon KM. Broad-spectrum CC-chemokine blockade by gene transfer inhibits macrophage recruitment and atherosclerotic plaque formation in apolipoprotein E-knockout mice. Circulation, 2004, 110(16): 2460-6.

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