Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey
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IPHY 3430 8-25-11 If you missed class on Tuesday, please pick up a syllabus from Dr. Carey . PowerPoint PPT Presentation


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IPHY 3430 8-25-11 If you missed class on Tuesday, please pick up a syllabus from Dr. Carey. Clicker question: What are your future plans? A. med school B. dental school C. physical therapy D. nursing E. other.

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IPHY 3430 8-25-11 If you missed class on Tuesday, please pick up a syllabus from Dr. Carey .

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Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

IPHY 3430 8-25-11If you missed class on Tuesday, please pick up a syllabus from Dr. Carey.


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

Clicker question:What are your future plans?A. med schoolB. dental schoolC. physical therapyD. nursingE. other


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

EnergeticsEnergy is the ability to produce change or an effect by doing work.Energy comes in several forms:heat, chemical, radiant, etc.


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

What is work in a human system?1. Synthesis of macromolecules2. Maintenance of ionic disequilibria3. Muscle contraction4. Transmission of information5. Many others


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

Chemical energy is the only form of energy that can be used to work in the human body.Bonds between C, H, N, S, O, etc. contain energy.Heat energy cannot be used to do work in the human body.


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

Where does energy for use in the human body come from?Chemical energy in food (carbohydrates, proteins, and fats)


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

Carbohydratescomplex carbohydrates (glycogen, starch) -->simple sugars (glucose, galactose, fructose)---> once absorbed into the body can be stored temporarily as glycogen or immediately catabolized-->energy released by enzymatic breakage of bonds ---> some work done and the rest lost as heat


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

ProteinsComplex proteins in diet --->broken down toamino acids--->once absorbed into body, amino acids can be used temporarily to make new proteins or immediately catabolized--->energy released by enzymatic breakage of bonds--> some work done and the rest lost as heat


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

FatsTriglycerides broken down to monoglyceride and two fatty acids-->Once absorbed into body, can be stored temporarily as triglycerides or split into glycerol and three fatty acids which then are catabolized-->energy released by enzymatic breakage of bonds --> some work done and the rest lost as heat


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

Summary:Chemical bonds in carbohydrates, proteins and fats are enzymatically broken, with the result that most chemical energy is lost as heat energy but some is conserved in chemical form to do work.


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

Heat energy is lost as chemical bonds are broken since products of cellular reactions frequently, but not always, have a lower energy content than the original moleculeA---> B + C


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

In living cells, chemical bonds must be broken in a step-by-step sequence, not all at once.1. Cell can’t use heat to do work2. Heat liberation would cause a lethal rise in cell temperature


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

Most of the energy in food is lost immediately as heat, but a small amount is used to form a few high energy bondsAdenosine triphosphateATP is the intermediary between the energy content of the food and the need to have chemical energy to do work.


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

Anaerobic conditions can occur

in periods of high energy demand;

lactate  lactic acid is formed,

increasing acidity in the tissue.

Figure 3-42


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

ATP ProductionGlycolysis1. Converts one 6-carbon molecule (glucose) into two three carbon molecules (pyruvate)2. Requires 2 ATP to start, generates 4 ATP, so produces a net 2 ATP3. H+ transferred to NAD+---> NADH4. If no Oxygen present, NADH loses H to pyruvate, forming lactate and regenerating NAD+


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

Each transition of pyruvate

to acetyl coenzyme A yields

one NADH and one CO2.

The acetyl coenzyme A

then enters the Krebs cycle.


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

In aerobic conditions,

two spins of the Krebs cycle

occur for each glucose

that enters glycolysis.


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

ATP ProductionCitric Acid Cycle1. Requires that oxygen be available2. 2 GTP ---> 2 ATP synthesized3. All 6 carbons and 6 oxygens from original glucose lost as CO24. The rest of all the original H+ on glucose transferred to NAD and FAD


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

Glucose catabolism “powers”

ATP synthesis via a combination of

substrate and oxidative phosphorylation.


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

For each NADH, 3 ATPs are formed.

For each FADH2, 2 ATPs are formed.


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

ATP ProductionOxidative Phosphorylation1. NADH and FADH2 oxidized to NAD+ and FAD+2. H separated into proton H+ and e-3. Electrons passed from cytochrome to cytochrome, with large energy drops at 3 steps, at which ATP made4. H+ combined with e-, O2 split, forming water5. 34 ATP made during this process


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

1 molecule of glucose produces2 ATP in glycolysis2 ATP in citric acid cycle22-34 ATP in oxidative phosphorylationTotal = 26-38 ATP --energy conversion is 38-44 % efficient electric motor or gasoline engine is 10-20% efficient


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

Fats are catabolized to make ATP1. Fatty acids broken down into 2-C fragments, enter as acetyl-CoA2. Glycerol enters glycolysis as 3-C1 molecule of palmitate (16 C fatty acid) = 84 ATP


Iphy 3430 8 25 11 if you missed class on tuesday please pick up a syllabus from dr carey

Amino Acids are catabolized to make ATPHOOC - C - NH2 R (one or more carbons)Enter as pyruvate, acetyl CoA or intermediate in citric acid cycle.


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