CTMS Knowledge Center: An Update

1. CTMS Knowledge Center: An Update Robert Annechiarico Mohammad Farid CTMS Workspace Call October 11, 2011

2. Today’s Talking Points • Mission Statement • CTMS Knowledge Center Team • Summary of Value Added Elements • Outreach Activities • Infrastructure Expansion • Software Adoption Support • Programmatic Concerns • Future Directions

3. Knowledge Center Mission Statement The CTMS Knowledge Center provides a central resource to house the critical informatics elements needed to execute clinical trials. Further, the Center is that point where the collection and integration of user and developer feedback facilitates a path to future improvement of workspace tools.

4. General Store / Crossroads Concept • A place to meet new people and exchange ideas • A well-stocked store; where the shopkeeper knows the product

5. Duke Bob Annechiarico, KC Director Mohammad Farid, Ops. Manager Madeline Carroll, RN, SME Jeffrey Allred, Systems Manager Chad McLamb, Webmaster Pankaj Agarwal, C3PR Project Mgr SemanticBits Paul Baumgartner, Tech Manager Kumar Sambhuni, Deployment Lead Biju Thomas, Web Developer Wesley Wiggins, Technical Writer Robert H. Lurie Comprehensive Cancer Center Warren Kibbe,PSC PI Dong Fu,PSC Senior Sys Admin/deployment CALGB Kim Johnson CTMS Knowledge Center Team

6. Summary of Value Added Elements • Provide support for end users • Installation and upgrading Suite install at adopter sites • Bug fixes and issue resolution of tools adopted in production • Fix issues with mapping data across CTMS tools • Hands-on training via conference calls and Web sessions • Respond to questions on the forums from adopters • Ongoing population and maintenance of the technology stack • Worked on creating a video for the CTMS Suite 2.3 • Start working on migration to Confluence Wiki • Wiki, forums, demo site, source code

7. Summary of Value Added Elements(cont.) • Update information related to CTMS tools and resources • Tools and documentation as organized on the Wiki • Installation and testing of CTMS Suite 2.3 demo complete • Update and maintain new version of of Suite 2.3 • VMware version of Suite 2.3 available • Participation in overall cross-KC effort • Contribute to bi-weekly cross-KC calls • Coordinate tools adoptions requiring cross-KC input • ex. caGRID integration

8. Outreach Activities • CTMS Face-to-Face meeting in Arkansas • The Society for Clinical Trials in Vancouver • Interactive booth (live software demos) • American Association Cancer Research (AACR) in Orlando • Interactive booth (live software demos) • Palmetto Open Source Software Conference (POSSCON) in Columbia, SC • Initial open source discussion forum

9. Outreach Activities (Cont.) • Joint Face to Face between ICR and Tissue Banking Workspaces in Bethesda, MD • Community Cancer Oncology Program (CCOP) • Continue to explore areas of synergy, • Lead by Kim Johnson • NCI Community Cancer Center Program (NCCCP) • Collaborate on Informatics Requirements Document

10. Reaching out via the Web Connection

11. Page Views (6 months)

12. Page Views (3 months)

13. CTMS Software Interest Trends

14. Infrastructure Expansion • CTMS Suite 2.3 Demo Site • Installed the latest Clinical Trial Suite version 2.3 released in May 2011 • Continue providing Demo site for Suite version 2.2 • Knowledge Base Expansion • Documentation updated with information related to Suite 2.3 • Tools landing pages are updated with Suite 2.3. • Video for the new tools • CTMS Suite 2.3 demo video showing the working of all CTMS tools integrated with other • C3PR video is available from the Wiki • Working on creating product videos caAERS

15. Infrastructure Expansion (Cont.) • Confluence Wiki • Knowledge Centers migrating to a common wiki platform • New platform provides users with: • Better integration with Jira • Facilitation of consolidated maintenance efforts at CBIIT • And, greater continuity across all Knowledge Centers • Issue tracking is now on ESN JIRA • Central location • All tools • Open access

16. JIRA User Friendly Functionality • Centralized tracking • All KCs • Easy to use • Tracks: • Bug Fixes • New Feature Requests • No login required to view issues

17. Issue Resolution and Enhancements Users Developers Governance

18. Total Posts 1,794 Total Topics 460 Total Members 259 In One year Visits 2,904 Page views 14,943 Avg. Time 6:46 min. CTMS KC Forum Traffic

19. Software Adoption Support • VU University Medical Center (Netherlands) • Support with Suite installation • Aga Khan University (Pakistan) • Upgrade Suite 2.2.1 to Suite 2.3 for the training instance • Facilitated validation • Fixed issue with caAERS MedWatchform • Mapping caAERS data to the MedWatch form • Adding additional pages to the MedWatch • Resolved C3PR adoption issues • Association of primary reason code to study subject • Issues with primary identifier for study subject and subjects • Query performance issue

20. Software Adoption Support (cont.) • Code sharing from Geisinger Medical Center (PA) • NCCCP Site • Had to re-install since CTMS Suite 2.3 ran into issues with local firewall • They automated some manual steps and created a wrapper script to accomplish fresh install of the CTMS Suite. • Shared with the CTMS KC which is being tested in our environment • Upgrade ready to use Virtual Machine • Used by Medical University of South Carolina (MUSC) in evaluating CTMS Suite for their needs

21. Significant Projects United States Roswell Park, NY Univ. of Missouri Mayo Clinic Thomas Jefferson Univ. Wake Forest Univ. Univ. of Minnesota Univ. of Arkansas CSS Assoc., CA Medical Univ. of SC Geisinger Med Center, PA St. Mary’s Health Care International Beijing Cancer Ctr. Einstein Cancer Ctr., (Beijing) BioMantra, India Univ. of Düsseldorf, FRG Univ. of Cologne, FRG Aga Khan Univ., Pakistan Immunovative Therapies Ltd, Israel Jikko Data Science Japan UV University Medical Center Netherlands CTMS KC Global Installation Support CTS caAERS C3PR C3D

22. Tools Support - National CTS caAERS C3PR PSC • caAERS • University of Missouri • CCS Associates, Inc., CA • Henry Ford Health System • Mayo Clinic Rochester • Wake Forest University Health • Roswell Park Cancer Institute • Cancer and Leukemia Group B • City of Hope Cancer Center • John Hopkins University • CTS • University of Arkansas for Medical Sciences • Duke Cancer Institute • Geisinger Medical Center, Pennsylvania • Medical University of South Carolina • C3PR • Kimmel Cancer Center, Thomas Jefferson University • Wake Forest University Health Science • Duke Cancer Institute • Saint Mary’s Health Care • PSC • Northwestern University • Mayo Clinic • City of Hope • Thomas Jefferson University • Saint Mary’s Health Care

23. Programmatic Concerns • Complex Support Model for CTMS Tools • Lack of development grants increases expectations from KC • Labviewer fixes without adoptions • C3PR issue resolution which are specific to institutions • International Support • Outreach • NCCCP – NCI Community Cancer Centers Program • CCOPS – Community Clinical Oncology Program

24. Future Directions • Open Source Development Emphasis • Coordination, functions • Advocacy role • Sandbox, NCI goals • Support user forums

25. Future Directions (Cont.) • Installing Medidata Rave on CTMS KC servers for demo • Include eHarmonization forms • Shift towards direct operations and maintenance support • Partner to develop patches and fix bugs • Outreach • Find new avenues for outreach such as CTSA

26. Questions and Answers