Translational Case Histories. Harvard Medical School Center for Biomedical Informatics i2b2 National Center for Biomedical Computing Isaac S. Kohane, MD, PhD John Glaser, PhD Susanne Churchill, PhD. First signal: 1 year after Celecoxib 8 months after Rofecoxib.
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Harvard Medical School
Center for Biomedical Informatics
i2b2 National Center for Biomedical Computing
Isaac S. Kohane, MD, PhD
John Glaser, PhD
Susanne Churchill, PhD
QIDS: Quick Inventory of Depressive Symptoms, self report
N = 943/2876
Very severe symptoms
Last QIDS-SR Score
Trivedi MH, et al. Am J Psychiatry 2006;163:28-40.
adds >95% specificity
SNP frequency in cases compared to controls
Positive controls: MHC, PTPN22, STAT4, TRAF1-C5, TNFAIP3
Protein protein interaction network
67 Conditions Total
Nuclear receptors: 31 of 67.
Interleukins: 38 of 67.
Insulin signaling: 45 of 67.