Controlling the quality of diagnostic tests
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Controlling the quality of diagnostic tests. E. Bravi. Precision & Accuracy. In the fields of science, engineering, industry, and statistics, the  ACCURACY of a measurement system is the degree of closeness of measurements of a quantity to that quantity's actual (true) value .

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Controlling the quality of diagnostic tests

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Controlling the quality of diagnostic tests

Controlling the quality of diagnostic tests

E. Bravi


Precision accuracy

Precision & Accuracy

  • In the fields of science, engineering, industry, and statistics, the ACCURACYof a measurement system is the degree of closeness of measurements of a quantity to that quantity's actual (true) value.

  • ThePRECISION of a measurement system, related to reproducibility and repeatability, is the degree to which repeated measurements under unchanged conditions show the same results.

  • Although the two words, precision and accuracy, can be synonymous in colloquial use, they are deliberately contrasted in the context of the scientific method.


Precision and accuracy

Precision and accuracy

Precise and accurate

Accurate

Neither precise, nor accurate

Precise


Purpose of the exercise

Purpose of the exercise

  • To check how the performance of different test results may influence the follow-up of patients submitted to a Gluten Free Diet in various clinical settings.


Materials available

Materials available

  • 7 vials containing ready-to-use samples.

  • Samples must not be diluted

  • Each sample has a different anti-tTG concentration

  • Anti-tTG concentration is unknown


Protocol

Protocol

  • Each centre will be assigned a code by MediCel

  • Register data results into the provided spreadsheet

  • Complete the spreadsheet and send it back to the evaluation centre

  • The evaluation centre will provide all participants with overall and their results


Assay protocol

Assay Protocol

  • Allow all reagents to reach room temperature

  • Run your own assay as usual

  • Include unknown samples as ready-to-use specimens

  • Register data results into the provided spreadsheet


How to report results

How to report results


Interpretation

Interpretation

  • Results will be used as follows:

    • All values:

      • To generate a consensus Mean.

      • To define acceptability range (Mean ± 2 St. Dev.)

      • and for each method:

      • To calculate Mean and Standard Deviation


Overall data example of graph

Overall data - Example of graph

+2 St Dev

Mean

-2 St. Dev

* *

* *

* *

* *

* *

1 2 3 4 5 6 7 8 9 10

Cumulative Mean

* Your lab

Lab #


Questions

Questions?

Thanks for your attention


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