Management of Rheumatoid Arthritis. *Note: At least four criteria must be fulfilled for classification as RA. Autoimmune/Genetic factors?. Other factors. Silica Dust Exposure Increased risk for RA in smokers Infections?- (EBV) Dietary Factors- ? red meat
*Note: At least four criteria must be fulfilled for classification as RA.
? red meat
? intake of fruit and oily fish may protect against RA
and stochastic factor contributions
multiple joints affected (30%)
hand only (25%)
Radiograph of the left hand. Soft tissue swelling is present around the MCP joints and wrist with diffuse narrowing of
MCP, PIP, and radiocarpal joint spaces.
Erosions are seen at the first CMC joint and distal ulna.
Periarticular osteopenia surrounds all of the articulations.
synovitis with pitting edema
Rheumatoid Nodules PIPs, and wrists seen in remitting seronegative symmetric
Anemia of chronic disease, lymphadenopathy
Vasculitis- sensorimotor neuropathy, nail-fold infarcts, leg ulcers, purpura, and digital gangreneExtra-ArticularManifestations
● Usual activities
“MTX is currently considered a first-line agent in the treatment of RA, and the “anchor drug” for combination therapy with other DMARDs and biologic agents. It has become the standard of care and the most widely used drug in the treatment of RA.”