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10 th International ISSX Meeting. September 30 – October 3, 2013 Westin Harbour Castle Hotel Toronto, Canada. Meeting Venue – Westin Harbour Castle Hotel. Proposed Meeting Organizing Committee (MOC). Denis Grant (Chair) Univ of Toronto ON Stelvio Bandiera UBC, Vancouver BC Jack Bend

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10 th International ISSX Meeting

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10 th international issx meeting

10th International ISSX Meeting

September 30 – October 3, 2013

Westin Harbour Castle Hotel

Toronto, Canada

Meeting venue westin harbour castle hotel

Meeting Venue – Westin Harbour Castle Hotel

Proposed meeting organizing committee moc

Proposed Meeting Organizing Committee (MOC)

Denis Grant (Chair)

Univ of Toronto ON


UBC, Vancouver BC

Jack Bend

UWO, London ON

Chantal Guillemette

Laval Univ, Quebec PQ


Celerion, Montreal PQ

Roger Keefe

Imperial Oil, Calgary AB

David K. Lee

NoAb, Mississauga, ON

Tom Massey

Queen’s Univ, Kingston ON

Eddie Morgan

Emory Univ, Atlanta GA

Sandy Pang

Univ of Toronto, Toronto ON

Allan Rettie

Univ of Washington, Seattle WA

David Riddick

Univ of Toronto, Toronto ON

Nathalie Rioux

BoehringerIngelheim, Laval PQ

Rachel Tyndale

Univ of Toronto, Toronto ON

Jack Uetrecht

Univ of Toronto. Toronto ON

Peter Wells

Univ of Toronto, Toronto ON

Proposed scientific advisory board sab

Proposed Scientific Advisory Board (SAB)

Ann Daly

– Newcastle University, UK

Patrick Dansette

- Université Paris, France

Xinxin Ding

– Wadsworth, Albany NY, USA


– University Hospital of Cologne, Germany

Ron Hines

– Medical College of Wisconsin, Milwaukee WI, USA

Paul Hollenberg

– University of Michigan, Ann Arbor MI, USA

Magnus Ingelman-Sundberg

– KarolinskaInstutute, Stockholm, Sweden

Tetsuya Kamataki

– Inst for Genome Function, Fujisawa, Japan

Richard Kim

– Univ of Western Ontario, London, ON, Canada

Steve Leeder

– Children's Mercy Hospital, Kansas City MO, USA

Peter Mackenzie

– Flinders University, Adelaide, Australia

Larry Marnett

– Vanderbilt Univ, Nashville TN, USA

Urs Meyer

– Biozentrum, Univ of Basel, Basel, Switzerland

Franz Oesch

– Univ of Mainz, Mainz, Germany

B. Kevin Park

- University of Liverpool, Liverpool, UK


- University of Oulu, Oulu, Finland

Lance Pohl

- NIH/NHLBI, Bethesda, Maryland, USA

Rory Remmel

- University of Minnesota, Minneapolis, Minnesota, USA

Glenn Sipes

- University of Arizona, Tucson, Arizona, USA

Bill Smith (President-Elect)

- Pfizer Inc La Jolla Labs, San Diego, California, USA

Steve Tannenbaum

- MIT, Cambridge, Massachusetts, USA

Ken Thummel

- University of Washington, Washington, USA

Jacques Turgeon

- Universite de Montreal, Montreal PQ, Canada

Mike Waterman

- Vanderbilt University, Nashville, Tennessee, USA

David Waxman

- Boston University, Boston, Massachusetts, USA

Yasushi Yamazoe

- Tohoku University, Sendai, Japan


- Dr. Margarete Fischer-Bosch Institute, Stuttgart, Germany

Meeting schedule overview

Meeting Schedule – Overview

  • 4-6 Short Courses

  • 3 Keynote Lectures

  • 2 Plenary Sessions

  • ISSX Awards and Award Lecture

  • 8-12 Symposia

  • 4-6 Industry-Sponsored Luncheon Seminars

  • 3 Days of Poster Viewing

  • 1 Poster Awards Session

  • 3 Days of Commercial Exhibits

  • ½ Day Free Time

  • Welcome Reception

  • ISSX Banquet

Meeting schedule timetable

Meeting Schedule - Timetable

Keynote lectures plenary sessions symposia and short courses

Keynote Lectures, Plenary Sessions, Symposia and Short Courses

Preliminary topics:

  • Role of inflammation in chemical carcinogenesis

  • Development and uses of stem cell derived hepatocyte-like cells and cultured transformed cells

  • Utility and challenges of genome-wide association studies in pharmacogenetics research

  • Extrapolation from in vitro and cell-based systems to predict in vivo human drug metabolism

  • Extrapolation of animal drug disposition studies to humans

  • Utility of genetically modified animals in human drug disposition studies

  • Toxicogenomic profiling: current status and future utility in drug development

  • Drug-metabolizing enzymes as therapeutic targets

  • Receptor cross-talk in the regulation of drug metabolizing enzyme expression

  • Metabolomic profiling as a tool for identifying novel drug target interactions

  • Role of oxidative stress in cell physiology and pathology

  • Pharmacogenomics and translational medicine: promise and challenge

  • Effect of natural products on drug disposition

  • Methods for prediction of drug-drug interactions

  • Systems biology and xenobiotic-host interactions: concepts and technologies

  • Impact of advanced genome sequencing technologies on personalized medicine

  • Neuronal damage and neuroprotection against chemical insult

  • DNA damage and repair mechanisms in cancer risk

  • Cell type specific cytotoxic mechanisms

  • New approaches to the development of biomarkers for drug-induced toxicity

Projected attendance

Projected Attendance

Members: 500

Non-members: 200

Students: 300




  • Oct 2011– May 2012 (24-16 mo)

    • MOC/SAB memberships approved and finalized (1 mo)

    • MOC/SAB meetings/teleconferences/email circulars – scientific program details finalized (7 mo)

  • May 2012 (16 mo)

    • Finalized program, speakers and titles sent to SAC

    • SAC approval of program

  • June – Oct 2012 (16-12 mo)

    • Speaker invitations

    • Identification/approval of satellite meetings

Toronto the city

Toronto – The City

Toronto exploring the city

Toronto – Exploring the City


  • Bloor Street

  • Yorkville

  • St. Lawrence Market

  • Eaton Centre

  • Distillery District

    Arts & Culture

  • Art Gallery of Ontario

  • Royal Ontario Museum

  • Toronto Symphony

  • Live Theatre

  • Opera

  • Sports: MLB Playoffs?!


  • Chinatown

  • Kensington Market

  • The Beaches

  • Little Italy

  • Queen Street West

  • Danforth/Greektown

  • Leaside

  • Roncesvalles Village

  • Bloor West Village


  • Harbourfront

  • Discovery Walk tours

  • ‘City of Ravines’

10 th international issx meeting1

10th International ISSX Meeting

September 30 – October 3, 2013

Westin Harbour Castle Hotel

Toronto, Canada

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