Resveratrol and Decreased Fat Deposition in C. elegans. Alexandra ******- Period 3 Manhasset Science Research. Need. Obesity Trends* Among U.S. Adults 1990, 1998, 2007. (*BMI 30, or about 30 lbs. overweight for 5’4” person). 1998. 1990. 2007.
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Resveratrol and Decreased Fat Deposition in C. elegans
Alexandra ******- Period 3
Manhasset Science Research
Obesity Trends* Among U.S. Adults1990, 1998, 2007
(*BMI 30, or about 30 lbs. overweight for 5’4” person)
No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30%
Source: Center for Disease Control & Prevention [http://www.cdc.gov/nccdphp/dnpa/obesity/trend/maps/obesity_trends_2007.ppt#487,5,Slide 5]
Figure 1: Chemical structure of Nile Red (A) & Sudan Black (B) staining. Nile Red staining in wild-type and mutant C. elegans (C-E). Sudan Black staining in wild-type (F) & mutant (G) organisms.
Source: (Ashrafi, 2007) [http://www.wormbook.org/chapters/www_obesity/obesity.html]
Figure 2: chemical structure of resveratrol (C14H12O3)
Figure 2: RNAi was used to silence certain genes to determine which ones regulated fat in C. elegans (Ashrafi, et al, 2003) [chart made by author using materials from article]
Figure 3: The enzyme AMPK is necessary for C. elegans in dauer to survive and regulate fat deposition (Roy, et al, 2009) [chart created by author]
Figure 4: Resveratrol caused many positive changes in the overall health of mice similar to the effects of caloric restriction
(Baur, et al, 2006) [chart made by author adapted from article]
Figure 5: In human preadipocytes (fat cell precursors), resveratrol in extremely high doses (3-5 g) caused positive changes in the cells. (Fischer-Posovsky, et al, 2008) [chart made by author]
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