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BioLume. Presentation January 10, 2007. BioLume Mission. …..to develop and commercialize a broad library of proprietary bioluminescent proteins with multiple first-in-class applications in diagnostic imaging, food, beverage, and cosmetics…. BioLume Imaging Patents.

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BioLume

Presentation

January 10, 2007

BioLume


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BioLumeMission

…..to develop and commercialize a broad library of proprietary bioluminescent proteins with multiple first-in-class applications

in diagnostic imaging, food, beverage, and cosmetics…..

BioLume


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BioLume Imaging Patents

  • Detection and visualization of neoplastic tissues and other tissues

    • U.S. 6,416,960 issued July 9, 2002

    • U.S. 6,596,257 issued July 22, 2003

    • U.S. 09/746485 filed December 22, 2000

  • Broad claims e.g., “A diagnostic system containing a bioluminescence generating system”

  • Backed up by broad composition of matter patents

BioLume


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Bioluminescence is light produced by a chemical reaction within a living organism

What is Bioluminescence?

BioLume


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Bioluminescent Proteins

Visible light

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BioLume’s bioluminescent proteins were cloned from various deep-sea marine organisms

Bioluminescent Proteins

BioLume


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Sardines, Herring, Haddock, Tuna, Salmon, and Mackerel all have diets rich in bioluminescent organisms and contain luciferases and their substrate coelenterazine

Bioluminescent Proteins

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Food squid observed during fishery collection

Bioluminescent Proteins

BioLume


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These proteins have already been tested for skin, eye, and oral toxicity (both acute and sub-acute)

These proteins were negative for mutagenicity in the Ames test.

Many pharmaceutical and university research laboratories have maintained animals expressing Luciferase, with no reports of toxicity or failure of animals or cells to thrive due to their presence.

Coelenterazine is a natural antioxidant

Bioluminescent Protein Safety

BioLume


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Molecular Imaging

Molecular imaging represents a paradigm shift in the focus of medical imaging from the visualization of anatomy and physiology to the study of metabolic and physiological processes e.g., cancers, often in real time

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Recent advances in biotechnology have enabled in vivo molecular imaging of luciferase reporter proteins in living animals by using a cooled charge-coupled device (CCD) camera.

Molecular Imaging

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Bioluminescent Imaging

BioLume


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Molecular Imaging

Because bioluminescence imaging has minimal background activity, this technology is very sensitive for detecting light emitted from luciferases

BioLume


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Bioluminescent Imaging

BioLume


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Bioluminescence Molecular Imaging with renilla luciferase

BioLume


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Bioluminescent Imaging

BioLume


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Bioluminescent Imaging

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Bioluminescent Imaging

BioLume


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Bioluminescent Imaging

BioLume


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  • >1 million new cases of skin cancer will be diagnosed in the US this year (>10k will die)

  • 1 in 5 Americans will develop skin cancer during their lifetime (BCC, SCC, or melanoma)

  • 1 in 65 Americans were likely to develop melanoma during their lifetime

  • Melanoma incidence has increased 690% since 1950

  • Melanoma is the second most common cancer in women aged 20 to 29

  • Source: American Academy of Dermatology

Skin Cancer Facts

BioLume


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  • Screening for skin cancer is a visual exam by patient or dermatologist

  • Suspicious lesions get a biopsy

  • Highly specific antibodies for melanoma are known and generically available

  • There are no skin cancer screening kits on the market today

Skin Cancer Detection

BioLume


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Immunology of Melanoma

  • There are unique surface antigens which characterize melanoma cells

  • These unique antigens can be used to target highly specific antibodies, for therapy or detection

BioLume


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Immunology of Melanoma

  • One type of surface antigen is a ganglioside (GM3)

  • Antibodies have been made which are directed against these gangliosides as well as other melanoma surface antigens

BioLume


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Selective melanoma antibody kill melanoma cells

BioLume


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Bioluminescent Melanoma Detection

Luciferases can be expressed with antibodies to melanoma surface antigen(s)

Or

Luciferases can be chemically conjugated to the melanoma antibodies

BioLume


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Summary

  • Product development opportunity combining known antibodies and developed bioluminescent proteins (no research required)

  • Patented bioluminescent proteins

  • Focused on an unmet medical need

  • Large market opportunity

BioLume


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