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09 生醫奈米粒子. 同材料奈米尺寸的粒子與較大尺寸的粒子,其光學等物理性質相異. Gold nanoparticles. The Lycurgus Cup dates from Roman times. The glass appears green in daylight (reflected light), but red when light is transmitted from the inside of the vessel. Gold nanoparticles in assay.

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09 生醫奈米粒子

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09 生醫奈米粒子

同材料奈米尺寸的粒子與較大尺寸的粒子,其光學等物理性質相異


Gold nanoparticles

Gold nanoparticles

The Lycurgus Cup dates from Roman times.

The glass appears green in daylight (reflected light),

but red when light is transmitted from the inside of the vessel.


Gold nanoparticles in assay

Gold nanoparticles in assay

their easily controllable-size distribution

long-term stability

and friendly biocompatibility with

antibodies, antigen proteins, DNA and RNA


Ssdna au nanoparticles

ssDNA-Au nanoparticles

  • 現行之DNA檢測技術中,以PCR為首之檢測技術,以及螢光染色法與放射性標誌等檢測方法。目前這些方法所能夠偵測之最小值有限,而且敏感度更是受到許多些微因素的影響。[G. H. Keller, M. M. Manak and N.Y. Stockton, “DNA Probes” (1989). ]


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1. Thaxton, C.S., Georganopoulou, D.G., Mirkin, C.A. 2006 Clin. Chim. Acta, 363, 120-126.

2. Sato, K., Hosokawa, K., Maeda, M. 2003 JACS, 125 , 8102-8103.


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(b)

(a)

DNA結合金奈米粒子之分析

穿遂式電子顯微鏡(TEM)之分析

圖12 以TEM觀測DNA-金奈米粒子分佈情形 (a) DNA(SH 1,SH2)/金奈米

粒子 (b)加入Linker 1後呈現聚集(assembly)的狀態


Single nucleotide polymorphism

Single-Nucleotide Polymorphism

Jishan Li, Xia Chu, Yali Liu, Jian-Hui Jiang, Zhimin He, Zhiwei Zhang,

Guoli Shen and Ru-Qin Yu

Nucleic Acids Research, 2005, Vol. 33, No. 19 e168


Antibody au nanoparticles

Antibody-Au nanoparticles

金奈米粒子的應用: 驗孕片之原理

(免疫層析法)


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Li, Alastair W. Wark, Hye Jin Lee, and Robert M. Corn Anal. Chem.2006, 78,3158-3164


Silver enhancement

Silver Enhancement


Colony printing

Colony Printing

綠膿桿菌

Salmonella


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複合奈米粒子:有趣的人造原子

陳東煌 成功大學化工系


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複合奈米粒子


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(b)

(a)


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(A)

Negative control 100 fmol 10 fmol 1 fmol 100 amol

10 amol 1 amol 100 zmol 10 zmol 1 zmol

(B)

Negative control 100 fmol 10 fmol 1 fmol 100 amol

10 amol 1 amol 100 zmol 10 zmol 1 zmol


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