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Being Positive for Decades and Running Out of Options

Being Positive for Decades and Running Out of Options. Introduction. Considerations in Aging PLWHIV. The Population of PLWHIV Is Aging. By 2030, Three-Fourths of the Population of PLWHIV Will Be >50 Years Old. Patient Case 1. Management of HIV and Management of Comorbidities Often Intersect.

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Being Positive for Decades and Running Out of Options

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  1. Being Positive for Decades and Running Out of Options

  2. Introduction

  3. Considerations in Aging PLWHIV

  4. The Population of PLWHIV Is Aging

  5. By 2030, Three-Fourths of the Population of PLWHIV Will Be >50 Years Old

  6. Patient Case 1

  7. Management of HIV and Management of Comorbidities Often Intersect

  8. Adherence Can Vary Throughout a Patient's Life and Is Affected by Numerous Factors

  9. Case 1: Management of Complicated Cases Requires Addressing Several Situations

  10. Objectives of Treatment

  11. The Aging Immune System

  12. General and HIV-Specific Mechanisms of Aging

  13. Case 1: How Does HIV Infection Affect Inflammaging?

  14. Beyond HIV Infection: Some ARV Classes Are More Suitable for Use in Older PLWHIV

  15. Case 1: Antiretroviral Therapy – Difficult to Balance the Benefits vs Risks

  16. Case 1: In Geriatric Setting, Consider Not Only DDIs, but Benefits and Risks of Each Drug

  17. Prescribing/Deprescribing in Elderly PLWHIV

  18. Clinical Trial Data Are Scarce on Older PLWHIV

  19. Clinical Management of HIV in Older Individuals Requires a Comprehensive Approach

  20. Advances in Drug Development and Technology Might Improve Outcomes in Older Patients

  21. Beyond HIV: Advances to Improve Outcomes in Older Patients

  22. Beyond HIV: Factors That Can Promote Healthy Aging

  23. Patient Case 2

  24. Case 2: Consequences of Multiple Suboptimal Treatments

  25. Case 2: Considerations for HIV Management in a Postmenopausal Woman

  26. Case 2: Objective of Treatment/Switching Is to Maintain Viral Suppression, Manage AEs

  27. Antiretroviral Therapy in Geriatric HIV Patients

  28. Case 2: Objective of Treatment/Switching Is to Maintain Viral Suppression, Manage AEs (cont)

  29. Case 2: Consider Monitoring Parameters in the Decision to Switch

  30. Case 2: Focus on the Whole Patient -- Other Factors Can Affect HIV Management

  31. Case 2: Advances in Drug Development and Technology Might Improve Outcomes in Older Patients (cont)

  32. Case 2: Focus on Improving Healthcare Delivery for Older Individuals in Addition to Managing HIV Infection

  33. Case Conclusions

  34. Program Conclusions

  35. Program Conclusions (cont)

  36. Abbreviations

  37. Abbreviations (cont)

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