An Examination of the Role of the CKR5 ∆32 Allele in HIV Infection. A Brief Discussion on Table 2. as presented in: Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene.
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An Examination of the Role of the CKR5∆32 Allele in HIV Infection
A Brief Discussion on Table 2. as presented in: Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene
Michael Dean, * Mary Carrington, * Cheryl Winkler, Gavin A. Huttley, Michael W. Smith, Rando Allikmets, James J. Goedert, Susan P. Buchbinder, Eric Vittinghoff, Edward Gomperts, Sharyne Donfield, David Vlahov, Richard Kaslow, Alfred Saah, Charles Rinaldo, Roger Detels, Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study, Stephen J. O'Brien
Presented by Andrew Jackson
What about mutations of the CKR5 gene?
Eight molecular genetic variants were identified by Dean et. al (1996). However only one mutation, a 32-base pair (bp) deletion (CKR5 Δ32 ) which causes a frame shift at amino acid 185 was significant
The CKR5 Δ32 occurred in approximately 10 % of study cohort, the other seven variants we found were in less than 1% of the individuals studied .
Is there a difference in the CKR5 genotype distribution between HIV-1 infected and uninfectedindividuals?
This figure was constructed using the data for all six cohorts examined in Table 2. of Science, Dean et al. 273 (5283): 1856
There was a significant difference in the CKR5 genotype distribution between HIV-1 infected and uninfected individuals examined Of the individuals tested those which were homozygotes for the CKR5∆32, 17 in total, were all HIV-1 antibody negative This suggests that the CKR5∆32 allele is a recessive gene which offers phenotypic resistance to HIV-1 infection and antibody production
Dean M., M.Carrington, * C.l Winkler, G. A. Huttley, M. W. Smith, R. Allikmets, J. J. Goedert, S. P. Buchbinder, E. Vittinghoff, E. Gomperts, S. Donfield, D. Vlahov, R. Kaslow, A. Saah, C. Rinaldo, and R. Detels. 1996.Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene. Science (5283):1856-1862.