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AML1/Runx1 and oncogenic transformation . RUNT domain (DNA BINDING). Chr 21. Chr 8. 4 Nervy repressor domains. Translocation (8;21). In human myeloid leukemia =>. RUNT domain. 4 Nervy repressor domains. Lozenge Drosophila. Runt Drosophila. Runx D.rerio. Runx1 G.gallus.

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aml1 runx1 and oncogenic transformation
AML1/Runx1 and oncogenic transformation

RUNT domain (DNA BINDING)

Chr 21

Chr 8

4 Nervy repressor domains

Translocation (8;21)

In human myeloid leukemia =>

RUNT domain

4 Nervy repressor domains

mcoffee multiple sequence alignment and phylogenetic tree

Lozenge Drosophila

Runt Drosophila

Runx D.rerio

Runx1 G.gallus

RUNX1v2 H.sapiens

Runx1 R.norvegicus

0.1

Runx1 M.musculus

Mcoffee: multiple sequence alignment and phylogenetic tree

RUNX1 alignment

slide3

(Drosophila)

NO alignment between species for the t(8;21)

slide5

Predicted structures of AML1-ETO domains

NCBI- BLAST

RUNT

Zf

NRH2 domain

PDB- models database

aml1 eto hydrophobic cluster analysis with drawhca

Phosphorylation site?

Phosphorylation site?

AML1-ETO: hydrophobic cluster analysis with drawhca

Runt

TAFH(NHR1)

NHR2

NHR3

zf-NHR4

conclusions
Conclusions:
  • Biocomputing study of AML-1 ETO
    • Sequences comparison vs AML-1
    • 3D prediction
    • Hydrophobic domains prediction
    • Potential phosphorylation sites of AML1

Comparison with AML1-ETO

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