Aml1 runx1 and oncogenic transformation
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AML1/Runx1 and oncogenic transformation . RUNT domain (DNA BINDING). Chr 21. Chr 8. 4 Nervy repressor domains. Translocation (8;21). In human myeloid leukemia =>. RUNT domain. 4 Nervy repressor domains. Lozenge Drosophila. Runt Drosophila. Runx D.rerio. Runx1 G.gallus.

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AML1/Runx1 and oncogenic transformation

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Aml1 runx1 and oncogenic transformation

AML1/Runx1 and oncogenic transformation

RUNT domain (DNA BINDING)

Chr 21

Chr 8

4 Nervy repressor domains

Translocation (8;21)

In human myeloid leukemia =>

RUNT domain

4 Nervy repressor domains


Mcoffee multiple sequence alignment and phylogenetic tree

Lozenge Drosophila

Runt Drosophila

Runx D.rerio

Runx1 G.gallus

RUNX1v2 H.sapiens

Runx1 R.norvegicus

0.1

Runx1 M.musculus

Mcoffee: multiple sequence alignment and phylogenetic tree

RUNX1 alignment


Aml1 runx1 and oncogenic transformation

(Drosophila)

NO alignment between species for the t(8;21)


Aml1 runx1 and oncogenic transformation

Is there a difference between the proteinic folding

of AML1

and AML1-ETO??


Aml1 runx1 and oncogenic transformation

Predicted structures of AML1-ETO domains

NCBI- BLAST

RUNT

Zf

NRH2 domain

PDB- models database


Aml1 eto hydrophobic cluster analysis with drawhca

Phosphorylation site?

Phosphorylation site?

AML1-ETO: hydrophobic cluster analysis with drawhca

Runt

TAFH(NHR1)

NHR2

NHR3

zf-NHR4


Scanning for phosphorylation sites of aml1 scansite

Scanning for Phosphorylation-sites of AML1: Scansite

ERK-1


Conclusions

Conclusions:

  • Biocomputing study of AML-1 ETO

    • Sequences comparison vs AML-1

    • 3D prediction

    • Hydrophobic domains prediction

    • Potential phosphorylation sites of AML1

      Comparison with AML1-ETO


Aml1 runx1 and oncogenic transformation

.....and now you have to return to the lab and make experiments...........


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