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Original Article Childhood Body-Mass Index and the Risk of Coronary Heart Disease in Adulthood. Jennifer L. Baker, Ph.D., Lina W. Olsen, Ph.D., and Thorkild I.A. Sørensen, M.D., Dr.Med.Sci. N Engl J Med Volume 357(23):2329-2337 December 6, 2007. Study Overview.

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Original ArticleChildhood Body-Mass Index and the Risk of Coronary Heart Disease in Adulthood

Jennifer L. Baker, Ph.D., Lina W. Olsen, Ph.D., and Thorkild I.A. Sørensen, M.D., Dr.Med.Sci.

N Engl J Med

Volume 357(23):2329-2337

December 6, 2007


Study overview
Study Overview

  • In this Danish study, body-mass index in childhood was associated with coronary heart disease (CHD) events in adulthood

  • The association was stronger in boys than in girls, and the risk of an event in adulthood increased in both sexes as the child's age increased from 7 to 13 years

  • These important data focus attention on the public health significance of the epidemic of childhood obesity


Mean BMI Values for 276,835 Children 7 to 13 Years of Age

Baker JL et al. N Engl J Med 2007;357:2329-2337


Body-Mass Index (BMI) in Childhood and the Risk of Coronary Heart Disease (CHD) in Adulthood

Baker JL et al. N Engl J Med 2007;357:2329-2337


Adjusted Hazard Ratio for the Risk of a Fatal or a Nonfatal CHD Event in Adulthood in Relation to a 1-Unit Increase in BMI z Score in a Cohort of 276,835 Children

Baker JL et al. N Engl J Med 2007;357:2329-2337


Adjusted Hazard Ratio for the Risk of Any CHD Event in Adulthood in Relation to a 1-Unit Increase in BMI z Score in Models Unadjusted and Adjusted for Birth Weight in a Cohort of 208,433 Children

Baker JL et al. N Engl J Med 2007;357:2329-2337


Predicted Risk of Having a CHD Event between 25 and 60 Years of Age in a Cohort of 276,835 Children of Average or Higher-Than-Average BMI

Baker JL et al. N Engl J Med 2007;357:2329-2337


Conclusion
Conclusion of Age in a Cohort of 276,835 Children of Average or Higher-Than-Average BMI

  • Higher BMI during childhood is associated with an increased risk of CHD in adulthood

  • The associations are stronger in boys than in girls and increase with the age of the child in both sexes

  • Our findings suggest that as children are becoming heavier worldwide, greater numbers of them are at risk of having CHD in adulthood


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