Hypothalamic & Pituitary Hormones. Kaukab Azim, MBBS, PhD. Uses of Hypothalamic & Pituitary Hormones. Short stature due to hypopituitarism (Pituitary dwarfism) Acromegaly and gigantism Carcinoid syndrome, VIPoma , and ruptured esophageal varices Hyperprolactinemia
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Kaukab Azim, MBBS, PhD
Growth hormone releasing hormone(GHRH)
Used rarely as a diagnostic test for GH responsiveness
IGF-1 as Peripheral effector
Most of the actions of GH are mediated by IGF-1(somatomedins)- the peptides produced in the liver and cartilage.
The somatomedins stimulate skeletal growth, amino acid transport, protein synthesis, nucleic acid synthesis and cell proliferation.
Short stature due to Congenital/acquired GH deficiency (Pituitary Dwarfism)
GH deficiency in adults
AIDS related muscle wasting
Increased Intracranial tension
Carpal tunnel syndrome
once every 4 weeks
To prevent gigantism
Secretion of prolactin is under the control of dopamine (prolactin inhibiting hormone)secreted by hypothalamus
Drugs to manage hyperprolactinemia:
Actions meditated through
IP3/DAG ↑ Ca+2
Drug induced SIADH:
Drugs to manage SIADH