Pharmacology Overview

Pharmacology Overview PowerPoint PPT Presentation


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Year 2 pharmacology. 1st termPharmacokinetics and PharmacodynamicsPharmacology of the Autonomic Nervous SystemParasympatheticSympathetic2nd termPharmacology of other systemsCVS system, Neuro, Opiates, Anaesthetics, Diuretics, etc.. Year 2 pharmacology. 1st termPharmacokinetics and PharmacodynamicsPharmacology of the Autonomic Nervous SystemParasympatheticSympathetic2nd termPharmacology of other systemsCVS system, Neuro, Opiates, Anaesthetics, Diuretics, etc..

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Pharmacology Overview

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1. Pharmacology Overview Muslim Medics 2nd year tutorial

2. Year 2 pharmacology 1st term Pharmacokinetics and Pharmacodynamics Pharmacology of the Autonomic Nervous System Parasympathetic Sympathetic 2nd term Pharmacology of other systems CVS system, Neuro, Opiates, Anaesthetics, Diuretics, etc.

3. Year 2 pharmacology 1st term Pharmacokinetics and Pharmacodynamics Pharmacology of the Autonomic Nervous System Parasympathetic Sympathetic 2nd term Pharmacology of other systems CVS system, Neuro, Opiates, Anaesthetics, Diuretics, etc.

4. cholinomimetics Agonists at Cholinergic Receptors Where would you find cholinergic receptors?

7. cholinomimetics Agonists at Cholinergic Receptors Where would you find cholinergic receptors? All preganglionic receptors All postganglionic receptors in PNS Postganglionic sweat gland receptors in SNS

8. cholinomimetics Agonists at Cholinergic Receptors Where would you find cholinergic receptors? All preganglionic receptors (Nicotinic) All postganglionic receptors in PNS (Muscarinic) Postganglionic sweat gland receptors in SNS (Musc)

9. cholinomimetics What is the difference in structure between nicotinic and muscarinic receptors? Nicotinic Ion channel Muscarinic G protein coupled

10. Effects of pns and sns Eye Salivary glands Bronchi Heart Gut Bladder

12. Glaucoma treatment What classes of drugs can be used?

13. Glaucoma treatment What classes of drugs can be used? Muscarinic receptor agonists Example? Which nerve? How?

14. Pns actions on the eye Accommodation Contracts ciliary muscle Relaxes suspensory ligament Lens gets fatter Focus for near vision Miosis (pupillary constriction) Contracts sphincter pupillae (circular muscle of iris) Pupil constricts Allows drainage of aqueous humour

15. Pns actions on the eye Accommodation Miosis (pupillary constriction)

17. Glaucoma

18. Glaucoma treatment What classes of drugs can be used? Sympathomimetics Example? How?

19. Adrenaline and glaucoma Three actions on eye Contracts dilator pupillae (radial muscle of iris) Reduces drainage of aqueous humour Doesn’t help glaucoma Acts on B2 receptors in ciliary body Increases production of aqueous humour Doesn’t help glaucoma Acts on alpha1 receptors in eye ? vasoconstriction REDUCES PRODUCTION OF AQEOUS HUMOUR HELPS GLAUCOMA THIS IS THE MAIN ACTION

20. Glaucoma treatment What classes of drugs can be used? B blockers Example How?

21. B blockers and glaucoma Main actions in eye Stops contraction of dilator pupillae (radial muscle of iris) This will increases drainage of aqueous humour Helps glaucoma Blocks B2 receptors in ciliary body Decreases production of aqueous humour Helps glaucoma No action on alpha1 receptors

22. Summary of glaucoma treatment Muscarinic agonists Pilocarpine Anticholinesterases Physostigmine Sympathomimetics Adrenaline B blockers Timolol Carbonic Anhydrase Inhibitors CA is a pathway in the G protein coupling to produce aqeuous humour

23. Any other questions?

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