Fast Electrical Impedance Spectroscopy measurement techniques for dynamic
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Fast Electrical Impedance Spectroscopy measurement techniques for dynamic bioimpedance characterization. Ph.D. Student: B.Sánchez Thesis Advisor: R.Bragós. Electronic Engineering Department Universitat Politècnica de Catalunya. Contents. 1.- Introduction 2.- Motivation

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Fast Electrical Impedance Spectroscopy measurement techniques for dynamicbioimpedance characterization.Ph.D. Student: B.SánchezThesis Advisor: R.Bragós

Electronic Engineering Department

Universitat Politècnica de Catalunya


Contents techniques for dynamic

1.- Introduction

2.- Motivation

3.- Multitone Burst Signal

4.- Results

5.- Conclusions


Introduction techniques for dynamic

Linear Time Invariant system: Impedance

Transfer Function

Laplace/Fourier Transform

1


Ro techniques for dynamic

|Z|

R

8

f

fc

Introduction

Biologicalsystems: Bioimpedance

EquivalentCircuit

Cellmembrane

Extracellularmatrix

LF

HF

2


Introduction techniques for dynamic

Ex-vivo tissuecharacterization:

3


Introduction techniques for dynamic

In-vitro staticcellculturegrowthcharacterization:

4


Motivation techniques for dynamic

Challenge (I): In-vitro myocites cell culture growing characterization for tissue engineering applications

Link video

5


Motivation techniques for dynamic

Challenge (II): In-vivo myocitespatchmonitoring and characterization:

6


Multitone Burst Signals techniques for dynamic

Time domain:

7


Multitone Burst Signals techniques for dynamic

Frequency domain:

8


Multitone Burst Signals techniques for dynamic

Crest Factor:

Schroeder:

Newman:

Genetic Algorithm:

9


Multitone Burst Signals techniques for dynamic

Frequency Plan:

Avoid intermodulation products: shift original tones for BW guard.

10


Multitone Burst Signals techniques for dynamic

Multitone bursts with Bilateral Quasi Logarithmic Frequency Distribution:

11


Results techniques for dynamic

Measurement Hardware Setup:

  • Custom FPGA based arbitrary signal generator.

  • DAC 12bits, 16Msamples, 40Ms/s, 1st order hold.

  • Ethernet capable controller.

  • PXI solution

  • PXI-5422: AWG, 200Ms/s, 32MB,16 bits.

  • PXIe-5122: AD 2channels, 100Ms/s, 64MB/channel, 14bits.

  • PXI-2530: multiplexation matrix, 128 channels.

12


Results techniques for dynamic

Yeast cell suspension settlement characterization:

Estimation of the Growth Cell Curve

13


Conclusions techniques for dynamic

  • Non invasive and non destructive technique for passive electrical properties charaterization of biological materials.

  • Valid measurement method for cell growth estimator and suitable for dynamic biological materials and systems characterization.

  • Wide application areas: electroporation, tomography, cell counting in microfludic, biosensors, tissue engineering,..

  • The final application field is the cardiac tissue characterization in regenerative medicine applications.

14


Fast Electrical Impedance Spectroscopy measurement techniques for dynamicbioimpedance characterization.Ph.D. Student: B.SánchezThesis Advisor: R.Bragós

Electronic Engineering Department

Universitat Politècnica de Catalunya


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