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Hemoglobin level significantly impacts the tumour cell survival fraction in humans after internal radiotherapy: application of a preclinical radiobiology model to clinical data. Stephan Walrand, Renaud Lhommel, Pierre Goffette, Marc Van den Eynde, Stanislas Pauwels, François Jamar

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  1. Hemoglobin level significantly impacts the tumour cell survival fraction in humans after internal radiotherapy: application of a preclinical radiobiology model to clinical data. Stephan Walrand, Renaud Lhommel, Pierre Goffette, Marc Van den Eynde, Stanislas Pauwels, François Jamar Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Avenue Hippocrate 10, 1200 Brussels, Belgium stephan.walrand@uclouvain.be

  2. Dose-effect relationship labeled with patient Hb level Hb Enhancement Factor k=0 k>0 HEF = 1 + k (Hb – 13) HEF HEF OER 1 1 let see in the following animation what will happen if we increase k Hb Hb (Gy) HEF x D 13 Hb 10 tumor cells survival fraction R2 = 0.53 13 13.4 k = 0.00 11 14.8 Hb 13.4 14.3 UCL Brussels

  3. - (Gy) HEF x D tumor cells survival fraction R2 = 0.53 k = 0.01 UCL Brussels

  4. (Gy) HEF x D tumor cells survival fraction R2 = 0.56 k = 0.02 UCL Brussels

  5. (Gy) HEF x D tumor cells survival fraction R2 = 0.60 k = 0.03 UCL Brussels

  6. (Gy) HEF x D tumor cells survival fraction R2 = 0.63 k = 0.04 UCL Brussels

  7. (Gy) HEF x D tumor cells survival fraction R2 = 0.66 k = 0.05 UCL Brussels

  8. (Gy) HEF x D tumor cells survival fraction R2 = 0.69 k = 0.06 UCL Brussels

  9. (Gy) HEF x D tumor cells survival fraction R2 = 0.72 k = 0.07 UCL Brussels

  10. (Gy) HEF x D tumor cells survival fraction R2 = 0.75 k = 0.08 UCL Brussels

  11. (Gy) HEF x D tumor cells survival fraction R2 = 0.78 k = 0.09 UCL Brussels

  12. (Gy) HEF x D tumor cells survival fraction R2 = 0.80 k = 0.10 UCL Brussels

  13. (Gy) HEF x D tumor cells survival fraction R2 = 0.83 k = 0.11 UCL Brussels

  14. (Gy) HEF x D tumor cells survival fraction R2 = 0.85 k = 0.12 UCL Brussels

  15. (Gy) HEF x D tumor cells survival fraction R2 = 0.87 k = 0.13 UCL Brussels

  16. (Gy) HEF x D tumor cells survival fraction R2 = 0.89 k = 0.14 UCL Brussels

  17. (Gy) HEF x D tumor cells survival fraction R2 = 0.90 k = 0.15 UCL Brussels

  18. (Gy) HEF x D tumor cells survival fraction R2 = 0.91 k = 0.16 UCL Brussels

  19. (Gy) HEF x D tumor cells survival fraction R2 = 0.92 k = 0.17 UCL Brussels

  20. (Gy) HEF x D tumor cells survival fraction R2 = 0.93 k = 0.18 UCL Brussels

  21. (Gy) HEF x D tumor cells survival fraction R2 = 0.93 k = 0.19 UCL Brussels

  22. (Gy) HEF x D tumor cells survival fraction R2 = 0.93 k = 0.21 UCL Brussels

  23. optimal HEF per patient (Gy) HEF x D tumor cells survival fraction R2 = 0.93 k = 0.23 R2 optimum UCL Brussels

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