Cpcrn mission
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CPCRN Mission. To accelerate the adoption of evidence-based cancer prevention and control in communities. CDC/NCI Interagency Collaboration. Dissemination Joint interest CDC/NCI (Application/Research) Complimentary strengths Shared interest in cancer Shared vision of CDC and NCI

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Cpcrn mission

CPCRN Mission

To accelerate the adoption of evidence-based cancer prevention and control in communities.


Cdc nci interagency collaboration

CDC/NCI Interagency Collaboration

  • Dissemination

    • Joint interest

      • CDC/NCI (Application/Research)

    • Complimentary strengths

  • Shared interest in cancer

  • Shared vision of CDC and NCI

    • Cancer care in the United States needs to improve.

    • Our investment in research needs to affect practice


Changes at nci

Changes at NCI

  • Welcome a new team leader

    • Russ Glasgow PhD

  • Continue the same team

    • Cynthia Vinson

    • Michael Sanchez

  • Continue the same emphasis

    • Turning your vision 900 to your work

      • Measuring & understanding the dissemination process


What we expect of you

What we expect of you

  • Short term products

    • At least one all site project

      • Progress in your own projects

    • Active working groups to achieve the goals

    • Consider the SIP announcement

      • FQHC, connection to Comprehensive Cancer

      • Use of existing cancer control resources (Planet)

  • Intellectual power

    • Synthesis/integration/evaluation

  • Progress in the measurement of dissemination

  • Expanded collaboration

    • I’ll welcome you at NCI


I m on to other work

I’m on to Other work

  • Two big initiatives on the horizon

    • Multilevel interventions

    • Population Registries Opitmizing Screening through Personalized Regimens (PROSPR)


Cpcrn mission

Multilevel Interventions in Health Care: Building the Foundation for Future Research

NCI Team

Stephen Taplin, MD MPH, Steve Clauser PhD

Rebecca Anhang Price PhD, Erica Breslau PhD, Veronica Chollette MS RN, Heather Edwards PhD, Irene Prabhu Das PhD

External Consultants

Arny Kaluzny PhD

Martin Charns PhD, Maria Fernandez Phd, Mary Fennel PhD, Ernie Hawk MD, Tom Vogt MD, Jane Zapka ScD


Health care is a process affected by multiple contextual influences

Health care is a process affected by multiple contextual influences


We need to conduct research that evaluates these effects

We need to conduct research that evaluates these effects

  • Traditional focus

    • Individual/family

    • Individual/physician

    • Effects of context on individual behavior

  • Little examination of interactions among contextual influences

  • Little examination of interventions that affect multiple levels (e.g. 3 or more)


Conference on the horizon

Conference on the Horizon

  • Multilevel Interventions in Health Care: Building the Foundation for Future Research

    • March 4-5, 2011, in Las Vegas, NV

    • Guided by an external consulting committee

  • JNCI supplement

    • 11 Papers that grew out a June 2009 meeting

  • Focus on factors affecting implementation

    • Contextual influences


Focus on research translation and implementation

Focus on Research Translation and Implementation

Discoveries

(e.g. genetic

risk factor)

T1: Epi, Cohorts, Biobanks

Candidate

Application

(e.g. test)

  • Trials

  • Phase I

  • Phase II

  • Phase III

  • Phase IV

T2: Clinical studies, RCTs

Evidence based

Guideline/

Policy

T3: Implementation Research

Practice &

Control

Programs in

Communities

T4: Outcomes

Research

PROSPR

Reducing the

Burden of

Disease in

Communities

Adapted from Khoury et al; Gen Med 2007


Prospr objectives

PROSPR Objectives

Primary

Study the comparative effectiveness and outcomes of existing and emerging cancer screening processes

Breast

Colon

Cervical cancer.

Study the balance of benefits and harms of cancer screening across recognized cancer risk levels

Secondary

Share data and conduct preliminary studies relevant to future innovative research to optimize the screening process.

75 million over 5 years

9-12 sites, 1 statistical coordinating center

National Cancer Institute

U.S. DEPARTMENT

OF HEALTH AND

HUMAN SERVICES

National Institutes

of Health


Thanks

Thanks

  • It has been my pleasure and my privilege to work with you

  • You are in good hands


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