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Nasopharyngeal Angiofibroma. Dr. Vishal Sharma. Definition. Benign tumor of nasopharynx (?), locally invasive, extremely vascular & occurs in adolescent males. Hamartomatous nidus of vascular tissue, dependent on testosterone. Synonyms: nasopharyngeal fibroma,

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Nasopharyngeal Angiofibroma

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Nasopharyngeal angiofibroma l.jpg

Nasopharyngeal Angiofibroma

Dr. Vishal Sharma

Definition l.jpg


  • Benign tumor of nasopharynx (?), locally invasive, extremely vascular & occurs in adolescent males.

  • Hamartomatous nidus of vascular tissue, dependent on testosterone.

  • Synonyms:nasopharyngeal fibroma,


Site of origin l.jpg

Site of origin

Arises in posterior nasal cavity, near superior

border of sphenopalatine foramen

Sphenopalatine foramen l.jpg

Sphenopalatine foramen

Pathology l.jpg


Gross: Sessile, bi-lobed, rubbery, red-pink or gray in colour. Histology:Encapsulated, composed of vascular tissue & fibrous stroma. Vessels are thin-walled, lack elastic fibers & smooth muscle (this leads to uncontrolled bleeding).

Histopathology l.jpg


Small tumour l.jpg

Small tumour

Nasal cavity l.jpg

Nasal cavity

Nasal cavity p n s l.jpg

Nasal cavity & P.N.S.

Nasopharynx l.jpg


Pterygopalatine fossa l.jpg

Pterygopalatine fossa

Infratemporal fossa l.jpg

Infratemporal fossa

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Infratemporal fossa

Cheek l.jpg


Orbit l.jpg


Sphenoid sinus l.jpg

Sphenoid sinus

Middle cranial fossa l.jpg

Middle cranial fossa

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Pituitary & Cavernous sinus

Spread l.jpg


Anterior:Nasal cavity + paranasal sinus


Lateral:goes to Pterygopalatine fossa

1. Infratemporal fossa  cheek

2. Inferior orbital fissure  orbit

Spread20 l.jpg


Superior:1. Sphenoid sinus

 Middle cranial fossa

 Cavernous sinus

 Optic chiasma

 Pituitary fossa

2. Skull base

 Middle cranial fossa

Symptoms l.jpg


1. Nasal obstruction(80-90%)with denasal

speech (rhinolalia clausa)

2. Epistaxis (50-60%): Persistent, Painless,

Profuse, Paroxysmal, Unprovoked

3. Headache (25%)

4. Facial swelling (20%): cheek & palatal swelling

Facial swelling l.jpg

Facial swelling

Signs l.jpg


1. Nasal or Nasopharyngeal mass (80%)

2. Frog-face deformity:

proptosis + nasal bridge broadening

3. Otitis media with effusion: due to E.T. blockage

4. Trismus: involvement of pterygoid muscle

5. Involvement of II, III, IV, VI cranial nerve

C t scan p n s with contrast l.jpg

C.T. scan P.N.S. with contrast

  • Extent of tumor

  • Anterior bowing of posterior maxillary wall (Miller Holman’s antral sign)

  • Tumor enhancement

  • Bone destruction

Other investigations l.jpg

Other Investigations

 M.R.I.:for intra-cranial involvement

 Digital Subtraction Angiography (D.S.A.):a. extent of tumor b. tumour blush (due to increasedvascularity)c. feeding arteries for embolization

 Biopsy: contraindicated (profuse bleeding)

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Magnetic Resonance Imaging

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D.S.A. before embolization

D s a after embolization l.jpg

D.S.A. after embolization

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Differential diagnosis

  • Rhabdomyosarcoma

  • Antrochoanal polyp

  • Teratoma

  • Dermoid

  • Encephalocoele

  • Inverting papilloma

  • Squamous cell carcinoma

Staging l.jpg


Stage I: Tumor limited to nasal cavity or

nasopharynx with no bony destruction Stage II:Tumor invading pterygopalatine

fossa or paranasal sinusesStage III: Tumor invading infratemporal

fossa or orbit or parasellar region Stage IV:Tumor invading cavernous sinus

or optic chiasma or pituitary fossa

Pre op reduction of tumor vascularity l.jpg

Pre-op reduction of tumor vascularity

1. Embolization of feeding arteries: with Gelfoam

2. Oestrogen therapy:Diethylstilbestrol (2.5 - 5

mg orally t.i.d. for 3 - 6 wk)

3. Testosterone receptor blocker:Flutamide

4. Pre-operative radiotherapy

5. Cryotherapy of tumor

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Trans-palatal approach

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Trans-palatal approach

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Trans-palatal approach

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Sardana’s approach

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Endoscopic approach

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Lateral rhinotomy approach

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Lateral rhinotomy approach

Midfacial degloving l.jpg

Midfacial degloving

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Denker’s incision

Caldwell Luc incision extended medially till midline

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Le Fort 1 osteotomy

Infratemporal fossa approach l.jpg

Infratemporal fossa approach

Anterior subcranial approach l.jpg

Anterior subcranial approach

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Surgical approaches

1. Trans-palatal approach (Wilson)

small tumour in nasopharynx

2. Sublabial + Trans-palatal approach (Sardana) large tumour of nose + PNS + nasopharynx

3. Intranasal endoscopic approach small tumour in nose / PNS / nasopharynx

Surgical approaches45 l.jpg

Surgical approaches

4. Transmaxillary approach via:

 Extended lateral rhinotomy incision

 Midfacial degloving incision

 Denker’s extended Caldwell-Luc incision

 Le Fort 1 osteotomy approach

Done for extension into pterygopalatine fossa

Surgical approaches46 l.jpg

Surgical approaches

5. Infratemporal fossa approach (Fisch) extension into infratemporal fossa

6. Anterior subcranial approach intracranial & orbital extension

7. Image-guided, endoscopic, laser-assisted

removal (latest): small / medium size tumors

Surgical specimen l.jpg

Surgical specimen

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Surgical specimen

Proton stereotactic radiation therapy p s r t l.jpg

Proton Stereotactic Radiation Therapy (P.S.R.T.)

Synonym:Gamma knife surgery

Used for: 1. Intracranial extension

2. Recurrence after surgery

  • Single relatively high dose of radiation delivered precisely to a small area to kill tumorcells

  • Minimal injury to adjacent nerves & brain tissue

Stereotactic radiotherapy l.jpg

Stereotactic Radiotherapy

Thank you l.jpg

Thank You

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