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Insulinoterapia

Carrera de Enfermería

Farmacología 17 de mayo 2010

Terapia Farmacológica en Diabetes Mellitus

EU-Lic. Rene Castillo Flores

Unidad de Fisiología y Farmacología

Universidad Santo Tomás

Sede Temuco - Chile


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Historia

  • 1921, Los fisiólogos canadienses Frederick G. Banting y Charles H. Best extrajeron por primera vez la insulina del tejido pancreático de los perros.


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Historia

  • 1922, administraron 15 ml de insulina exógena a un paciente diabético Leonard Thompson y su glicemia disminuyó de 440 a 320 mg/dL.

  • 1923 Premio Nóbel de Medicina descubrimiento de la insulina, MacLeod y Banting.


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Década 50

Insulina lenta

Década 40

Protamina Neutra Hagedorn (NPH)

Década 30

Insulina Protamina Zinc (PZI),

Historia


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Historia

1996

FDA aprobó el primer

análogo de insulina la Lispro

Década 80

Análogos de insulina

(ADN recombinante)

Década

60-70

Insulinas purificadas.


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PANCREAS

Acinos pancreáticos

Células δ 5-10% (somatostatina)

Célula α 20% (glucagon)

Célula β (insulina) 70%

Islotes de Langerhans



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