NIH Office of Extramural Research

1. NIH Office of Extramural Research EB2013/FASEB – April 2013 NIH Training and Fellowship Programs, and Loan RepaymentHenry Khachaturian, Ph.D.NIH Extramural Program Policy Officer Director of Policy, NIH Loan Repayment ProgramsOffice of Extramural Research, NIHEmail: hk11b@nih.gov 1

2. National Institutes of Health Our mission is to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce the burdens of illness and disability. • World’s largest source of funding for biomedical research • Support more than 300,000 research personnel at over 3,000 universities and research institutions • 27 Institutes and Centers (ICs) with specific research agendas

3. FY 2015 President’s Budget: $30,361,653 $767,132 Training $626,778 Career $1,393,910 NIH Budget Office: http://officeofbudget.od.nih.gov/index.htm

4. NIH New Investigators Programs • NRSA Individual and Institutional Training Awards • Individual Fellowships • Research Career Development Awards • Fellowship Review Criteria • NIH Loan Repayment Programs 4

5. Training & Career Development Support 2014 ‘Formal’ Training/Career Awards Research Awards Career Stage Pre-Bac Institutional Training Grant (T34) Pre-Bac GRADUATE/ MEDICAL STUDENT Predoctoral Institutional Training Grant (T32) Predoctoral Individual NRSA (F31) Predoctoral Individual MD/PhD NRSA (F30) ‘Informal’ Training and Career Development on RPGs and Supplements Postdoctoral Institutional Training (T32) Postdoctoral Individual NRSA (F32) $767M POST DOCTORAL $627M NIH Pathway to Independence (PI) Award (K99/R00) Mentored Research Scientist Development Award (K01) Mentored Clinical Scientist Development Award (K08) Mentored Patient-Oriented RCDA (K23) Mentored Quantitative RCDA (K25) EARLY Small Grant (R03) Research Project Grant (R01) Independent Scientist Award (K02) CAREER MIDDLE Midcareer Investigator Award in Patient-Oriented Research (K24) Exploratory/Develop-ment Grant (R21) SENIOR Senior Scientist Award (K05) 5

6. Advice for Mapping Your Career With NIH • Review Institute/Center (IC) priorities and goals. Each IC has a research training and career development program. • Learn the NIH application and review process • Identify the grant programs offered by each IC • Make early contact with program officers • Find innovative, well-respected mentors and collaborators • Study successful grant applications- talk to your mentor • Propose your best and most creative ideas

9. Research Training Awards Authority • Established by the NRSA Act of 1974. • Section 487 of PHS Act; Regulations at 42 CFR 66. • Replaced all previous NIH training authority. • Name change legislation passed August 2002. • Supported by 22 of the 24 awarding NIH Institutes and Centers (FIC and NLM have own authority). • Supported by the Agency for Health Care Research and Quality (AHRQ) and the Health Resources Services Administration (HRSA). • 2 types of awards: • Institutional, e.g. T32, T34, T35, T90/R90. • Individual, e.g. F30, F31, F32, F33.

10. National Research Service Award Policies Policies that apply to both Training Grants and Fellowships… Guidelines: • NIH Grants Policy Statement, Kirschstein—NRSA Section:http://grants.nih.gov/grants/policy/nihgps_2003/NIHGPS_Part10.htm#_Toc54600187 • Program Announcements & Other Information:http://grants.nih.gov/training/nrsa.htm

11. Citizenship Requirements • Must be Citizen, non-citizen national, or lawfully admitted for permanent residence • Permanent Residents: • Fellowships: Must have been admitted as a Permanent Resident by the time of award • Training Grants: Must have been admitted as a Permanent Resident at time of appointment

12. Degree Requirements • Pre-Baccalaureate: Currently enrolled as an honors undergraduate at designated institutions (MARC and COR trainees). • Predoctoral: Must have a baccalaureate degree and be enrolled in doctoral program leading to PhD or equivalent, or dual research/clinical doctorate such as the MD/PhD. • Postdoctoral: Must have a PhD or MD or comparable doctoral degree from an accredited domestic or foreign institution.

13. NRSA Limitations Duration of Support: • Predoc: 5 years* • Postdoc: 3 Years • Aggregate limits apply: any combination from individual and/or institutional awards Exceptions: • Physicians/Clinicians (*combined-degree F30 allows 6 years) • Interruptions (break in service) • Waiver request requires IC prior approval

14. Ruth L. Kirschstein National Research Service Awards • NRSA Opportunities: • Training grants (Ts): Multi-slot awards that are used to support research training activities for several individuals. • Fellowships (Fs): Awards for graduate students working on a doctoral degree and researchers who have just earned their doctorates (postdocs). Overview: The overall goal of the NIH Ruth L. Kirschstein National Research Service Award (NRSA) program is to help ensure that a diverse pool of highly trained scientists is available in appropriate scientific disciplines to address the Nation's biomedical, behavioral, and clinical research needs.

15. NRSA Fellowships Overview: • Awarded to Predoctoral or Postdoctoral fellows who are working with mentors. • Training can be at domestic or foreign institutions. • Opportunities in basic and/or clinical research. • Open to any scientific area within the NIH scientific mission. • PhDs and MD/PhDs receive most of the awards. F-Kiosk: http://grants.nih.gov/training/F_files_nrsa.htm Core Review Criteria: • Fellowship Applicant – Academic record and training, publications, etc. • Sponsors, Collaborators, and Consultants • Research Training Plan • Training Potential • Institutional Environment & Commitment to Training Additional Review Consideration: • Training in the Responsible Conduct of Research

16. F30 and F31 Predoctoral Fellowships Overview: • Support Predoctoral Fellows during graduate (possibly medical) training. • F30 (MD/PhD) may support up to 6 years of training. • F31 is limited to 5 years total. • Promising doctoral candidates who will be performing dissertation research. • Some Institutes and Centers only support Diversity F31s. • Fellows may not change the scope, move fellowship, or change mentor without prior NIH approval! Program Features: • Stipend: • FY 2015: $22,920 • Tuition/Fees: • 60% of requested tuition, capped at $16,000 ($21,000 for MD/PhD programs) • Institutional Allowance: • $4,200 • Includes health insurance • Travel Allowance: • Part of IA

17. F32 Postdoctoral Fellowships Overview: • Support Postdoctoral research training. • Promising fellows with the potential to become productive, independent investigators in scientific health-related research fields relevant to the missions of NIH Institutes & Centers. • NRSA support for up to 3 years total. Awardees incur two years of payback. • Repay the 1st year by staying in research a 2nd year • Fellows may not change the scope, move fellowship, or switch mentor without prior NIH approval! Program Features: • Stipends: • FY 2014: $42,000 (Level-0) to $55,272 (Level-7) • Tuition/Fees: • 60% of requested tuition, capped at $4,500 ($16,000 for those seeking another doctoral degree) • Institutional Allowance: • $7,850 • Includes health insurance • Travel Allowance: • Up to $1,000

18. Kirschstein-NRSA training grants and fellowships Pre- and Post-Doctoral full-time training positions awarded

19. Kirschstein-NRSA pre-doctoral fellowships (F31s) Applications, awards, and success rates

20. Kirschstein-NRSA post-doctoral fellowships (F32s) Applications, awards, and success rates

21. The NIH Review Process My Application xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx Center for Scientific Review PI / Institution Submits application Assigns IRG in CSR or IC Scientific Review Group Evaluates Scientific Merit Revision / Resubmission Institute or Center (IC) Evaluates Relevance Advisory Council Recommends Action $$$ Allocates Funds IC Director Conduct Research

22. Fellowship Review Criteria (1 of 5) Fellowship Applicant: • Are the applicant’s academic record and research experience of high quality? • Does the applicant have the potential to develop into an independent and productive researcher in biomedical, behavioral or clinical science? • Does the applicant demonstrate commitment to a career as an independent researcher in the future?

23. Fellowship Review Criteria (2 of 5) Sponsors, Collaborators, and Consultants: • Are the sponsor(s’) research qualifications (including recent publications) and track record of mentoring individuals at a similar stage appropriate for the needs of the applicant? • Is there evidence of a match between the research interests of the applicant and the sponsor(s)? Do the sponsor(s) demonstrate an understanding of the applicant’s training needs as well as the ability and commitment to assist in meeting those needs? • Is there evidence of adequate research funds to support the applicant’s proposed research project and training for the duration of the fellowship? • If a team of sponsors is proposed, is the team structure well justified for the mentored training plan, and are the roles of the individual members appropriate and clearly defined? • Are the qualifications of any collaborator(s) and/or consultant(s), including their complementary expertise and previous experience in fostering the training of fellows, appropriate for the proposed research project?

24. Fellowship Review Criteria (3 of 5) Research Training Plan: • Is the proposed research plan of high scientific quality, and is it well integrated with the proposed training plan? • Is the research project consistent with the applicant’s stage of research development? • Is the proposed timeframe feasible to accomplish the proposed research training? • Based on the sponsor’s description of his/her active research program, is the applicant’s proposed research project sufficiently distinct from the sponsor’s funded research for the applicant’s career stage?

25. Fellowship Review Criteria (4 of 5) Training Potential: • Do the proposed research project and training plan have the potential to provide the applicant with the requisite individualized and mentored experiences that will develop his/her knowledge and research and professional development skills? • Does the training plan take advantage of the applicant’s strengths and address gaps in needed skills? Does the training plan document a clear need for, and value of, the proposed training for the applicant? • Does the proposed research training have the potential to serve as a sound foundation that will clearly lead the fellow to an independent and productive research career?

26. Fellowship Review Criteria (5 of 5) Institutional Environment & Commitment to Training: • Are the research facilities, resources (e.g. equipment, laboratory space, computer resources, subject populations), and training opportunities (e.g. seminars, workshops, professional development opportunities) adequate and appropriate? • Is the institutional environment for the applicant’s scientific development of high quality? • Is there appropriate institutional commitment to fostering the applicant’s mentored training toward his/her research career goals?

27. NIH Office of Extramural Research Resources: • NIH Extramural Training Mechanisms: http://grants1.nih.gov/training/extramural.htm • Ruth L. Kirschstein National Research Service Award (NRSA): http://grants1.nih.gov/training/nrsa.htm • NIH Career Development Awards: http://grants1.nih.gov/training/careerdevelopmentawards.htm 27

28. Extramural Loan Repayment Programs • Clinical Research • Pediatric Research • Health Disparities Research • Contraception and Infertility Research • Clinical Research for Individuals from Disadvantaged Backgrounds

29. Extramural Loan Repayment Programs • In exchange for a two-year research commitment, NIH repays qualified educational debt up to $35,000 per year. Payments made to lenders. • Research must be funded by a domestic nonprofit, university or U.S. federal, state or local government entity. • Recipients conduct research for an average of at least 20 hours per week over a quarter. • Tax liability on the loan payments is partially offset. • Apply September 1 – November 15. • 1,600 researchers funded each year. Success rate is 40 percent for new applicants and 70 percent for renewals. • Additional Information: http://www.lrp.nih.gov/