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Side effects of anti-TB medications HREZ

Side effects of anti-TB medications HREZ. Isoniazid. Isoniazid -induced hepatitis-most common major toxic effect Peripheral neuropathy CNS toxicity-memory loss, psychosis,seizures Fever and skin rashes Drug-induced SLE Hematologic abnormalities Provocation of pyridoxine deficiency anemia

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Side effects of anti-TB medications HREZ

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  1. Side effects of anti-TB medications HREZ

  2. Isoniazid • Isoniazid-induced hepatitis-most common major toxic effect • Peripheral neuropathy • CNS toxicity-memory loss, psychosis,seizures • Fever and skin rashes • Drug-induced SLE • Hematologic abnormalities • Provocation of pyridoxine deficiency anemia • Tinnitus • Gastrointestinal discomfort Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 773

  3. Rifampicin • Orange urine, sweat and tears • Rashes • Thrombocytopenia • Nephritis • Light-chain proteinuria • Flu-like sydrome(fever, chills, myalgia, anemia and thrombocytopenia) Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 774

  4. Ethambutol • Retrobulbar neuritis • most common serious adverse event • Loss of visual acuity and red-green color blindness • Hypersensitivity syndrome consisting of cutaneous reaction (such as rash or exfoliative dermatitis) • Fever and lymphadenopathy Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 774 http://www.drugs.com/sfx/ethambutol-side-effects.html

  5. Pyrazinamide • Hepatotoxicity-major adverse effect • Nausea • Vomiting • Fever • hyperuricemia Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 775

  6. *Streptomycin • Vertigo and hearing loss • nausea, vomiting • paresthesia of face • rash • fever • Urticaria • angioneuroticedema • eosinophilia Katzung, B, Basic and Clinical Pharmacology 10th ed., McGraw Hill 2007, page 775 http://www.drugs.com/sfx/streptomycin-side-effects.html

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