A C2B2 Activity!. A Systems and Structural Biology approach to the dissection of complex biological phenotypes. Perhaps surprisingly, a concise definition of systems biology that most of us Can agree upon has yet to emerge. ( Ruedi Aebersold, Faculty Member ISB ). MAGNet: Organization.
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A C2B2 Activity!
A Systems and Structural Biology approach to the dissection of complex biological phenotypes
Perhaps surprisingly, a concise definition of systems biology that most of us
Can agree upon has yet to emerge. (Ruedi Aebersold, Faculty Member ISB)
Contacted Alfonso Valencia, Dafne Koller, and Soren Brunak to join the SAB
Generating High-Throughput Data
Reverse Engineering the Networks
The Evolution of Systems Biology
Understanding Cell Physiology / Disease
Physiologic / Pathologic
Regulatory Network: Mesenchymal Signature of High-grade Glioma
Identification of Transcription Factor (TF) targets
Identification of Protein-Protein Interactions in Complexes
Identification of post-translational TF modifiers (Kinases, …)
Identification of post-transcriptional TF modifiers (miRs)
Polymorphysms’ role in molecular interactions
Can it be done computationally from high-throughput data?
Can it be done accurately?
Can it be biochemically/biologically validated?
Integrated Genomics Platform
Support for gene expression data, sequences, pathways, structure, etc. (40+ visualization and analysis modules).
Access to local and remote data sources and analytical services.
Support for workflow scripting.
Integration with caGRID.
Martha Bulyk (RG), Andrea Califano (SB), Manolis Kellis (RG), Gustavo Stolovitzky (DR)
Sun Nov 2
Wed Oct 29