Enhance
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ENHANCE. Mean carotid IMT 0.0058 ± 0.0037 mm in the simvastatin arm vs. 0.0111 ± 0.0038 mm in the ezetimibe/simvastatin arm (p = 0.29) Mean LDL levels 192.7 mg/dl (39% ↓ ) in simvastatin arm, 141.3 mg/dl in the ezetimibe/simvastatin arm (56% ↓ ) (p < 0.01). (p = 0.20). (p < 0.01).

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ENHANCE

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Enhance

ENHANCE

Mean carotid IMT 0.0058 ± 0.0037 mm in the simvastatin arm vs. 0.0111 ± 0.0038 mm in the ezetimibe/simvastatin arm (p = 0.29)

Mean LDL levels 192.7 mg/dl (39% ↓) in simvastatin arm, 141.3 mg/dl in the ezetimibe/simvastatin arm (56% ↓) (p < 0.01)

(p = 0.20)

(p < 0.01)

Ezetimibe/ Simvastatin

(n = 357)

Simvastatin

(n = 363)

Trial design:Patients with heterozygous familial hypercholesterolemia were randomized to treatment with ezetimibe/simvastatin 10/80 mg or simvastatin 80 mg alone. Mean change in intima-media thickness (IMT) was measured in the carotid arteries over 2 years.

Results

4.7

5

193

4

200

2.8

141

3

150

%

mg/dl

2

Conclusions

100

  • No additional benefit in carotid IMT reduction at 2 years with ezetimibe/simvastatin compared with high-dose simvastatin alone

  • LDL lowering greater with ezetimibe/simvastatin

  • Clinical outcomes and adverse events similar

1

50

0

0

LDL cholesterol

New plaque formation

Kastelein JJ, et al. N Engl J Med 2008;358:1431-43


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