Cervical Cancer
This presentation is the property of its rightful owner.
Sponsored Links
1 / 38

Cervical Cancer Screening Recommendations 2012, PowerPoint PPT Presentation


  • 75 Views
  • Uploaded on
  • Presentation posted in: General

Cervical Cancer Screening Recommendations 2012, FDA Panel 2014. Goals of Screening ( & Management). Prevent Morbidity and mortality from Cervical Cancer Not find HPV infection Not find abnormal cytology.

Download Presentation

Cervical Cancer Screening Recommendations 2012,

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Cervical cancer screening recommendations 2012

Cervical Cancer

Screening

Recommendations

2012,

FDA Panel 2014


Cervical cancer screening recommendations 2012

Goals of Screening ( & Management)

Prevent Morbidity and mortality from

Cervical Cancer

Not find HPV infection

Not find abnormal cytology

Prevent Overzealous management of

precursor lesions likely to regress or

disappear for which the risks of

management outweight the benefits


Cervical cancer screening recommendations 2012

The new screening recommendations address

age-appropriate screening strategies

Initial screening primary screening approach

Starting age

Screening frequency ( interval)

Screening in olderwomen

and after hysterectomy

Stopping age

Special Population


Cervical cancer screening recommendations 2012

Frequency

(Interval)

The frequency of testing is dependent upon the screening test used.


Cervical cancer screening recommendations 2012

SCREENING MODALITIES

Pap Test ; conventional or Liquid > = 21 y

every 3 year

Co-testing; every 5 year

pap smear + hrHPV test ; only ≥ 30 Y

Primary, Stand-alone HPV test ;

≥25 Y every 3 year

only FDA Approve: Cobas test


Cervical cancer screening recommendations 2012

Screening Interval

Risk of developing invasive cancer

before next screen

should be unlikely


Cervical cancer screening recommendations 2012

Rationale for Longer Pap

Screening Intervals

Sensitivity of Single Pap test 50-70%

Cancer risk 1.5/100,000

Cancer risk 4.7/100,000

99,997 women screened unnecesarily to help 3


Cervical cancer screening recommendations 2012

RISKS OF SCREENING 

MISUSE and Harms


Cervical cancer screening recommendations 2012

2014 NEWS

What’s NEW


Cervical cancer screening recommendations 2012

Other Issues to Consider with Cytology

  • Highly subjective test: substantial inter-and intra-laboratory variability and limited reproducibility

  • Unable to identify those women who are at future risk of developing cervical cancer precursors

  • Unclear how cytology will perform as HPV vaccine uptake rates increase in the US


Cervical cancer screening recommendations 2012

Summary of HPV Primary Screening for Cervical Cancer

FDA approval of cobasHPV test, April, 2014

Athena end of trial results

–>40,000 participants ≥ age 25

–Followed up in 3 years if HPV test negative

–Colposcopy if HPV 16+ or 18+

–Cytology if HPV 16 neg. or 18 neg.


Cervical cancer screening recommendations 2012

Concerns raised by the FDA Panel(and others….)

Education, education, and

more education

3 screening options =

more confusion?


Cervical cancer screening recommendations 2012

سپاس


  • Login