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Aim : How is protein shape determined?

Aim : How is protein shape determined?. Do Now : Protein Synthesis Questions. HW :. Look around, how does your creations compare to everyone else’s?. Build Whatever You Want. Do they all look the same? Why not? You all had the same Lego pieces.

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Aim : How is protein shape determined?

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  1. Aim: How is protein shape determined? Do Now: Protein Synthesis Questions HW:

  2. Look around, how does your creations compare to everyone else’s? Build Whatever You Want • Do they all look the same? Why not? You all had the same Lego pieces. • How can we use this analogy to describe the connections between a protein and the DNA sequence that produced it?

  3. How is a protein’s function determined? • All proteins have a specific shape that determines their function. Hormone Enzymes Hemoglobin Antibodies

  4. How is protein shape determined? • A protein’s shape is determined by its sequence of amino acids. • What determines the sequence of amino acids? • Ultimately the DNA (Transcription – Translation)

  5. How does a protein change after translation? It gets folded into a specific shape. This shape is determined by the order of the amino acids in the chain.

  6. How does a mutated protein affect a cell? • The mutated DNA may code for the wrong enzyme, no enzyme or may have no effect on the cell at all.

  7. Activity - Types of Mutation • Substitution • Deletion • Insertion • Inversion Original DNA Strand

  8. Original DNA Strand Mutated DNA Strand

  9. Original DNA Strand A One base is substitutedfor another. Substitution -

  10. Original DNA Strand B Deletion - One base is deleted (removed).

  11. Original DNA Strand C Extra bases are added to the genetic code. Insertion -

  12. Original DNA Strand D The genetic code is inverted or reversed. Inversion -

  13. Sickle Cell Anemia • A genetic disorder resulting from a substitution mutation which leads to the addition of the wrong amino acid. This causes a red blood cell to have a “sickle” shape (can’t carry oxygen and gets stuck in blood vessels). • How can this be beneficial?

  14. Exit Card – Protein Shape Identify the four most common types of mutation. How do mutations in DNA affect protein shape? Extra Credit: What type of mutation is displayed below? Explain Original DNA - CCT CAA GAT GCG Mutated DNA - CCT AAC GAT GCG

  15. A B C

  16. D

  17. D D D

  18. Substitution – DNA CCT CAA GAT GCG mRNA GGG GUU CUA CGC Deletion – DNA CCT CAA GAT GCG mRNA GGA GUU CAC GC Substitution and Deletion Mutations One base is substitutedfor another. One base is deleted (removed).

  19. Insertion and Inversion Mutations Extra bases are added to the genetic code. • Insertion – DNA CCT CAA GAT GCG mRNA GGA UGU UCU ACG C • Inversion – DNA CCT CAA GAT GCG mRNA GGA UUG CUA CGC The genetic code is inverted or reversed.

  20. Use the chart to complete your hand out

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