Acute viral hepatitis
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Acute Viral Hepatitis. Viral Hepatitis. Infectious: Hepatitis A Serum : Hepatitis B, D NANB : Hepatitis C Hepatitis E. Viral Hepatitis Over View. Clinical Features. Sub clinical Clinical Non specific ( fever, myalgea, arthralgia, fatigue ..)

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Acute Viral Hepatitis

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Acute viral hepatitis

Acute Viral Hepatitis


Viral hepatitis

Viral Hepatitis

  • Infectious: Hepatitis A

  • Serum : Hepatitis B, D

  • NANB : Hepatitis C

    Hepatitis E


Viral hepatitis over view

Viral HepatitisOver View


Clinical features

Clinical Features

  • Sub clinical

  • Clinical

  • Non specific (fever, myalgea, arthralgia, fatigue..)

  • gastrointestinal (jaundice, itching, anorexia, pain..)


Hepatitis a

Hepatitis A

  • Incubation Period: 15-50 days

  • Clinical Hepatitis

    -<6y : <10%

    -6-14y : 40-50%

    -14y : 70-80%


Hepatitis b

Hepatitis B

  • Incubation Period: 45-180 days

  • Clinical Hepatitis

    -<5y : <10%

    ->5y : 30-50%

  • Chronic Infection:

    -<5y : 30-90%

    ->5y : 2-10%


Hepatitis c

Hepatitis C

  • Incubation Period: 2-26 Weeks

  • Clinical Hepatitis: 20%

  • Chronic Infection: 80%


Hepatitis d

Hepatitis D

  • HBV Co infection

    -Severe acute hepatitis

    -Low risk of chronic infection

  • HBV Super infection

    -High risk of chronic liver disease


Hepatitis e

Hepatitis E

  • Incubation Period: 15-60 days

  • Case fatality: 20% in pregnancy

  • Illness severity: Increase with age


Diagnosis

Diagnosis

  • Biochemical tests

  • Serum aminotransferases

  • Serum billirubin

  • albumin

  • Serology

  • Serum antigens / antibody

  • Nucleic acid detection (PCR)


Diagnosis1

Diagnosis

  • Serology

  • HAV-Ab IgM

  • HBsAg, HBeAg, HBcAb IgM

  • HCV Ab

  • HDV Ab IgM

  • HEV Ab IgM


Treatment

Treatment

  • Supportive management

  • Prevent infection spread

  • Specific antiviral therapy (may be considered for HBV & HCV)

  • Liver transplant for Fulminant hepatitis


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