Multiple alignment: Feng-Doolittle algorithm. Why multiple alignments?. Alignment of more than two sequences Usually gives better information about conserved regions and function (more data) Better estimate of significance when using a sequence of unknown function
Multiple alignment: Feng-Doolittle algorithm
Notice that this method does not guarantee the optimum alignment; just a good one.
Gaps are preserved from alignment to alignment: “once a gap, always a gap”