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Фёдорова Светлана среда, 6 марта, 16 часов. Checkpoints for Dummies:. введение в чекпойнтоведение. M -фаза: митоз, разделение хромосом, деление клетки. G 0 -фаза: фаза покоя, клетка не делится. G 2 -фаза: подготовка к митозу. S -фаза:

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введение в чекпойнтоведение

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3719780

, 6 , 16

Checkpoints for

Dummies:


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M-: ,

,

G0 -:

,

G2 -:

S-:

, , ,

G1 -: ,


Cdk cyc

CDK/Cyc-


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-

-CDK

CDK/Cyc, -

  • S.cerevisiae S.pombe Cdk1( cdc28 cdc2, )

  • Cdk1 Cdk2. Cdk4 Cdk6 .

  • , , 13 Cdk:

  • Cdk1,2,4,6 ,

  • Cdk Cdk- (CAK).


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CDK/Cyc

  • 4 :

  • G1 (Cln3 Sc D ) . , ,

  • G1/S (Cln1 Cln2 S. erevisiae, E ) G1- S-. , S-phaseCdk G1-; , .

  • S (Clb5, Clb6 S. erevisiae A ), . S S, G2- , .

  • - (Clb1,2,3 4 S. erevisiae B ). , . -, . .


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CDK/Cyc

1) . 2) (CDK ), , CDK7 Mat1. 3) CDK , Wee1 , - Cdc25. (Wee1 Cdc25) , . 4) CDK (CKI). CDK INK4 CIP/KIP.


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:


G1 start

G1-. (START)

  • G1- (), G1pm.

  • ( R - , , -START), .

  • R G1ps. , G1ps , .


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G0 -

  • R, (G0) , ( ):

  • (1) ,

  • (2) ,

  • (3) .

  • (G0) , -

  • G0- , S-. , G0, .


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G1


G1 s cyce cdk2

G1/S CycE/CDK2

G1/S- : .

S-, E2F-1/DP-1 - .

S-. 53 pRB , E2F-1/DP-1.

. , .

S

(S-) () , , , . . . S- 8-12 .


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S- E CDK2 A.E G1 CDK2 S- . .


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S/G2 CycA/CDK1

S- G2 A CDK1 CDK2. ( G2) .


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G2


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G2 M

  • () MPF (M phase promoting factor), M- . MPF CDK1 A B.


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:

G1/S- CycE/CDK2

S/G2 - CycA/CDK1

G2/M - CycB/CDK1


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. checkpoints


Checkpoint g1 s

checkpoint : G1/S


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G1/S-checkpoint

:

P53

Cdc25a


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DNA-replication checkpoint: S-

ATR= theataxiatelangiectasia

Rad3 related kinase

ATM= theataxiatelangiectasia mutated kinase

Chk1, 2= thecheckpoint kinase 1, 2


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Checkpoint ,

: G2/M


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() checkpoint: M-

MAD mitotic arrest deficient

BUB budding uninhibited

by benzimedazole

APC anaphase promoting

complex


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