1 / 8

Background

Substudy Blood Flow The effect of Nilvad ipine on: C erebral autoregulation, B lood pressure and cerebral blood F low and - D amage in A lzheimer’s D isease: a NILVAD CBF ADD-on study. Background. Amyloid β induced vasoconstriction. TCD/ NIRS. ASL. Cerebral autoregulation.

gay
Download Presentation

Background

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Substudy Blood FlowThe effect of Nilvadipine on: Cerebral autoregulation, Blood pressure and cerebral blood Flow and -Damage in Alzheimer’s Disease: a NILVAD CBF ADD-on study

  2. Background Amyloidβinducedvasoconstriction TCD/ NIRS ASL Cerebral autoregulation Cerebralperfusion Bloodpressure (variability) Impaired cognition Home BPM AD

  3. CBF ADD-on – method (1) Week 26 Baseline Week 78 Screening N=40, plus somepatientsfrom Arnhem Placebo n=20 AD patients (MMSE ≥ 12 and ≤ 26) Nilvadipine 8 mg n=20

  4. CBF ADD-on – method (2)

  5. CBF ADD-on – methode (3) Haemodynamic lab • cerebral autoregulation: NIRS/TCD, BP monitoring Protocol: • Sitting (baseline), • Sit-Stand • Repeated Sit-Stand • Hyperventilation • 5% CO2-inhalation

  6. CBF ADD-on – methode (4) MRI lab Completescanprotocol (~45 min) T1 (1x1x1 mm) 5:47 ASL (slice thickness 3 mm) 14:24 FLAIR (slice thickness 3 mm, nogap) 6:50 DTI (64 directions) 8:25 SWI (1x1x1 mm) 7:44 “I often doze off when I’m getting an MRI”- Melman, the hypochondriac giraffe from the movie Madagascar

  7. Status (1) Optimisation ASL protocol Support by Fraunhofer Mevis Institute Bremen (Prof. Matthias Günther, Dr. Thorsten Honroth) 4 healthyyoung, 3 healthyelderlyhavebeenscanned 2 or 3 moretobescanned Coverage: 30 slices, slice thickness 3mm, positionedalong AC-PC line Data analysis Learning ASL analysisJuly-August @ SAFE lab BIDMC Harvard (Dr. Vera Novak, David Alsop)

  8. Status (2) Finances: 2 Funds: ADDF ($380K), April 1 2013 – March 31 2015 Dutch Alzheimer Society (300KE) Nowtryingtocombinethetwointo 1 biggerproject, addingthedevelopmentof a clinicallyapplicablecerebralautoregulationmeasurementusing MRI. Dutch Alzheimer Society preparedtocontinuewhen ADDF ends.

More Related