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DEFINITIONS. NAME THAT ANTIGEN. DISEASE ASSOCIATION. KELL SYSTEM. ENZYMES. 1pt. 1 pt. 1 pt. 1pt. 1 pt. 2 pt. 2 pt. 2pt. 2pt. 2 pt. 3 pt. 3 pt. 3 pt. 3 pt. 3 pt. 4 pt. 4 pt. 4pt. 4 pt. 4pt. 5pt. 5 pt. 5 pt. 5 pt. 5 pt.

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DEFINITIONS

NAME THAT

ANTIGEN

DISEASE

ASSOCIATION

KELL

SYSTEM

ENZYMES

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This is the ability of an antigen to stimulate an antibody response.


Immunogenicity


This is the term for antigens that are present in less than 10% of the general population.


Low prevalence

Low frequency

Low incidence

Familial

Private


DAILY DOUBLE

This is a known failure of an antigen-antibody reaction to yield a positive test result as a consequence of antibody excess.


Prozone


This is the term for a reaction in which one cell population is agglutinated, but a second cell population remains free.


Mixed-field


What term has been used to denote those antibodies which react weakly both when diluted or undiluted, but are present in high concentration.


HTLA

(High Titer, Low Avidity)


After the ABO and Rh antigens, this antigen is the most immunogenic.


Kell


Name an antigen in the Kell system that is high prevalence.


k (Cellano)

Kpb ( Rautenberg)

Jsb (Matthews)


This antigen is formed by a non-secretor who has inherited the genes lele.


Lec


Anti-Tja is associated with this blood group system.


P


Name one antigen that is part of the C4 molecule of complement, and therefore not an intrinsic part of the RBC membrane.

(An example of an HTLA antibody)


Chido or Rodgers


This relatively uncommon antibody is found in up to 80% of patients with infectious mononucleosis.


Anti-i


This antigen, related to the Kell system, is associated with Chronic Granulomatous Disease.


Kx


The erythrocytes of individuals with this phenotype appear to resist invasion by

Plasmodium vivax.


Fy (a-b-)


The Donath-Landsteiner antibody that is present in the serum of patients with paroxysmal cold hemoglobinuria (PCH) has this specificity.


Anti-P


A patient with a Mycoplasma pneumoniae infection will most likely develop a cold autoantibody with this specificity.


Anti-I


Antibodies of the Kell system generally react at this phase of testing.


AHG


Give two reasons a patient who had anti-K two years ago now appears to be compatible with two random donor units of red blood cells.


  • Both units are K negative.

  • The anti-K titer is too low to be detected.


Name three pairs of antithetical antigens at the Kell locus.


  • K and k (Kell and Cellano)

  • Kpa and Kpb (Penny and Rautenberg)

  • Jsa and Jsb (Sutter and Matthews)


Individuals of the Kell null phenotype may only be transfused with RBCs from other Kell null individuals because their plasma contains this antibody.


Anti-Ku


A person with anti-K will be compatible with approximately this many random donors out of ten.


9


This enzyme is the most commonly used in routine Blood Banking.


Ficin


Papain is derived from this plant.


Papaya


Name 5 blood group antigens that are enhanced by enzymes.


Kidd, Lewis , Rh, Ii, P, ABO

(Kidd Lewis has Ripples In his Pecs and Abs.)


DAILY DOUBLE

Name 5 blood group antigens that are adversely affected by proteolytic substances.


MNS, Fy, Xga

(Many New Soldiers are destroyed in the Field by eXplosions.)

Note: Sometimes Kell (Many New Soldiers are Killed in the Field by eXplosions)


These antigens of the Duffy system are enzyme resistant.


Fy3, Fy5 (and Fy4)


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