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Kreatinine Verklaard !?

Explore the relationship between creatinine levels and chronic kidney disease in a 65-year-old diabetic, hypertensive white woman weighing 50 kilograms. Learn about the recommended creatinine thresholds for CKD and why creatinine reference intervals do not easily correlate with glomerular filtration rate (GFR).

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Kreatinine Verklaard !?

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  1. Introductie Kreatinine Verklaard !?

  2. At what level of creatinine does a 65-year-old diabetic, hypertensive white woman weighing 50 kilograms have chronic kidney disease (CKD)? > 83 µmol/L? > 133 µmol/L? > 177 µmol/L?

  3. At what level of creatinine does a 65-year-old diabetic, hypertensive white woman weighing 50 kilograms have chronic kidney disease (CKD)? 77% of physicians said: Creatinine > 133 µmol/L (>1.5 mg/dL) Actual eGFR at this creatinine = 37 mL/min/1.73m 2

  4. At what level of creatinine does a 65-year-old diabetic, hypertensive white woman weighing 50 kilograms have chronic kidney disease (CKD)? 77% of physicians said: Creatinine > 133 µmol/L (>1.5 mg/dL) Actual eGFR at this creatinine = 37 mL/min/1.73m 2 Creatinine = 83 µmol/L (0.94mg/dL) eGF R = 60 mL/min/1.73 m 2

  5. Relationship of Serum Creatinine to Inulin Clearance 7.0 6.0 5.0 4.0 3.0 2.0 1.0 0 GFR low normal limit Area denotes normal SCr with decreased inulin clearance Serum Creatinine, mg/dL Treshold for CKD 133 µmol/L SCr upper normal limit 0 20 40 60 80 100 120 Inulin Clearance, mL/min/1.73 m2

  6. Less than 20% of people with CKD are aware they have the disease 50 % 40 % 30 % 17.9 % 20 % 2.9 % 10 % 0 % Female Male Coresh, 2003 Why? creatinine reference interval does not easily correlate with GFR

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