Overview of Pre-hospital Pharmacology

Overview of Pre-hospital Pharmacology PowerPoint PPT Presentation


  • 194 Views
  • Uploaded on
  • Presentation posted in: General

Mechanism of Airway Hyperactivity. Decrease in baseline airway caliberAlterations in bronchial smooth muscle (hypertrophy, hyperplasia)Increased number of mast cellsIncreased synthesis of mediatorsLowered receptor thresholdDamage to airway epithelial cellsAlterations in ANS regulation:Increased parasympathetic activityDecreased b adrenergic responsivenessIncreased a adrenergic responsivenessDecreased responsiveness of nonadrenergic inhibitory system.

Download Presentation

Overview of Pre-hospital Pharmacology

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


1. Overview of Pre-hospital Pharmacology Lynn K. Wittwer, MD, MPD Clark County EMS

2. Mechanism of Airway Hyperactivity Decrease in baseline airway caliber Alterations in bronchial smooth muscle (hypertrophy, hyperplasia) Increased number of mast cells Increased synthesis of mediators Lowered receptor threshold Damage to airway epithelial cells Alterations in ANS regulation: Increased parasympathetic activity Decreased b adrenergic responsiveness Increased a adrenergic responsiveness Decreased responsiveness of nonadrenergic inhibitory system

3. Cholinergic System Vagus (Ach) bronchoconstriction at rest cholinergic stimulation predominates Asthma muscle mass bronchial tone Histamines (H1) bronchoconstriction Bronchoconstriction requires intracellular Ca

5. Immunology

6. Immunology

12. Cellular Metabolism

14. Respiratory

17. Cardiac

19. Cardiac (Antidysrhythmics)

21. Cardiac (Antidysrhythmics)

22. Cardiac (Antidysrhythmics)

23. Cardiac (Antidysrhythmics)

24. Cardiac (Antidysrhythmics)

33. Cardiac (Sympathomimetic)

  • Login