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Mechanism of Airway Hyperactivity. Decrease in baseline airway caliberAlterations in bronchial smooth muscle (hypertrophy, hyperplasia)Increased number of mast cellsIncreased synthesis of mediatorsLowered receptor thresholdDamage to airway epithelial cellsAlterations in ANS regulation:Increased parasympathetic activityDecreased b adrenergic responsivenessIncreased a adrenergic responsivenessDecreased responsiveness of nonadrenergic inhibitory system.

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Overview of Pre-hospital Pharmacology

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