Peripheral t cell lymphoma in 2013
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Peripheral T-Cell Lymphoma in 2013. Program Goal. WHO 2008 Classification of Mature T/NK-Cell Neoplasms. Use of the Term PTCL. PTCL, PTCL Mature (Post-Thymic) T-Cell Lymphomas. International PTCL Study: Major NHL Types by Region.

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Peripheral T-Cell Lymphoma in 2013

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Peripheral t cell lymphoma in 2013

Peripheral T-Cell Lymphoma in 2013


Program goal

Program Goal


Who 2008 classification of mature t nk cell neoplasms

WHO 2008 Classification of Mature T/NK-Cell Neoplasms


Use of the term ptcl

Use of the Term PTCL


Ptcl ptcl mature post thymic t cell lymphomas

PTCL, PTCL Mature (Post-Thymic) T-Cell Lymphomas


International ptcl study major nhl types by region

International PTCL Study: Major NHL Types by Region


Key points in the pathology characteristics of the most common subtypes of ptcl

Key Points in the Pathology Characteristics of the Most Common Subtypes of PTCL


Alk and alcl

ALK and ALCL


Outcomes by ptcl subtypes

Outcomes by PTCL Subtypes


Prognostic indices for ptcl

Prognostic Indices for PTCL


Peripheral t cell lymphoma in 2013

Autologous Stem Cell Transplantation as First-line Therapy in PTCL: Results of a Prospective Multicenter Study


Chop first line treatment of ptcl

CHOP: First-line Treatment of PTCL


Alemtuzumab a chemotherapy first line treatment of ptcl

Alemtuzumab (A) + ChemotherapyFirst-line treatment of PTCL


Chop and non chop first line treatment of ptcl

CHOP+ and Non-CHOP: First-line Treatment of PTCL


Peripheral t cell lymphoma in 2013

Treatment and Prognosis of Mature T-Cell and NK-Cell Lymphoma: Event-Free Survival of Younger Patients


Peripheral t cell lymphoma in 2013

Treatment and Prognosis of Mature T-Cell and NK-Cell Lymphoma: Event-free Survival of Younger Patients (cont)


Autologous stem cell transplantation as first line therapy in ptcl survival

Autologous Stem Cell Transplantation as First-line Therapy in PTCL: Survival


Prognostic factors in trials of asct in first remission

Prognostic Factors in Trials of ASCT in First Remission


Ice and planned asct for relapsed refractory t cell lymphoma pfs from ice

ICE and Planned ASCT for Relapsed/Refractory T-Cell Lymphoma: PFS From ICE


Cibmtr auto and allo for ptcl outcomes excluding patients in cr1

CIBMTR Auto and Allo for PTCL: Outcomes Excluding Patients in CR1


Retrospective analyses of allogeneic stem cell transplantation for ptcl

Retrospective Analyses of Allogeneic Stem-Cell Transplantation for PTCL


Approved agents in relapsed refractory ptcl

Approved Agents in Relapsed/Refractory PTCL


Propel adverse events gr 3 occurring in 3 of patients n 111

PROPEL: Adverse Events ≥ Gr 3 Occurring in ≥ 3% of Patients (n = 111)


Treatment related adverse events with romidepsin in 20 of patients n 131

Treatment-related Adverse Events With Romidepsin in ≥ 20% of Patients (N = 131)


Brentuximab vedotin phase 2 study in relapsed refractory systemic alcl

Brentuximab Vedotin: Phase 2 Study in Relapsed/Refractory Systemic ALCL


Brentuximab vedotin in relapsed alcl toxicities

Brentuximab Vedotin in Relapsed ALCL: Toxicities


Brentuximab best clinical response by disease diagnosis

Brentuximab: Best Clinical Response by Disease Diagnosis


Brentuximab maximum tumor volume reduction by frequency of cd30 cells

Brentuximab: Maximum Tumor Volume Reduction by Frequency of CD30+ Cells


Front line therapy study design combination therapy arms

Front-line Therapy: Study Design (Combination Therapy Arms)


Front line therapy best response by disease diagnosis

Front-line Therapy: Best Response by Disease Diagnosis


Bendamustine in t cell lymphoma bently trial

Bendamustine in T-Cell Lymphoma (BENTLY Trial)


Lenalidomide in relapsed refractory tcl phase 2 trial

Lenalidomide in Relapsed/Refractory TCL: Phase 2 Trial


Belinostat ptcl response assessed by central review

Belinostat: PTCL Response Assessed by Central Review


Belinostat response rate by cprg lymphoma diagnosis

Belinostat: Response Rate by CPRG Lymphoma Diagnosis


Belinostat grade 3 nonhematologic aes in patients with r r ptcl n 120

Belinostat: Grade ≥3 Nonhematologic AEs in Patients With R/R PTCL (N=120)


Mln8237 response pr cr by histology

MLN8237: Response (PR + CR) by Histology


Ipi 145 a pi3k inhibitor

IPI-145: A PI3K-δ,γ Inhibitor


Early signs of clinical activity of ipi 145 in t cell lymphoma

Early Signs of Clinical Activity of IPI-145 in T-Cell Lymphoma


Mogamulizumab kw 0761 anti ccr4 monoclonal antibody

Mogamulizumab (KW-0761)Anti-CCR4 Monoclonal Antibody


Recommended approach to patients with relapsed ptcl nos aitl alcl

Recommended Approach to Patients With Relapsed PTCL (NOS, AITL, ALCL)


Abbreviations

Abbreviations


Abbreviations cont

Abbreviations (cont)


Abbreviations cont1

Abbreviations (cont)


Abbreviations cont2

Abbreviations (cont)


References

References


References cont

References (cont)


References cont1

References (cont)


References cont2

References (cont)


References cont3

References (cont)


References cont4

References (cont)


References cont5

References (cont)


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