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Metabolic Breakdown of Individual Amino Acids. to Citric Acid Cycle Intermediates or their Precursors. Glucogenic Pyruvate – a -Ketoglutarate Succinyl-CoA Fumarate Oxaloacetate. Ketogenic Acetyl-CoA Acetoacetate. Products of Amino Acid Breakdown.

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Metabolic breakdown of individual amino acids l.jpg

Metabolic Breakdown of Individual Amino Acids

to

Citric Acid Cycle Intermediates

or

their Precursors


Products of amino acid breakdown l.jpg

Glucogenic

Pyruvate

– a-Ketoglutarate

Succinyl-CoA

Fumarate

Oxaloacetate

Ketogenic

Acetyl-CoA

Acetoacetate

Products of Amino Acid Breakdown


Slide3 l.jpg

Animals cannot carryout net synthesis of precursors of gluconeogenesis from acetyl-CoA or acetoacetate



Degradation to pyruvate l.jpg

Degradation to Pyruvate

Alanine, Cysteine, Glycine, Serine and Threonine



Cysteine l.jpg

Cysteine

(Various Routes)



Glycine serine l.jpg

Glycine —> Serine

Serine Hydroxymethyl Transferase





Threonine serine l.jpg

Threonine —> Serine

Serine Hydroxymethyl Transferase

(PLP and C–C Bond Cleavage)






N 5 n 10 methylene tetrahydrofolate l.jpg
N5, N10-Methylene Tetrahydrofolate


Source of n 5 n 10 methylene tetrahydrofolate l.jpg

Source ofN5, N10-Methylene Tetrahydrofolate

Glycine Cleavage System

Glycine Decarboxylase Multienzyme Complex

or

Glycine Synthase (reverse direction)


Glycine cleavage system l.jpg
Glycine Cleavage System

  • P-Protein: PLP-dependent glycine decarboxylase

  • H-Protein: lipoamide-containing protein

  • T-Protein: THF-requiring enzyme

  • L-Protein: NAD+-dependent FAD-requiring dihydrolipoyl dehydrogenase


Glycine cleavage system formation of glycine plp schiff base l.jpg
Glycine Cleavage System (Formation of Glycine-PLP Schiff Base)


Glycine cleavage system decarboxylation and transfer of 1 carbon unit l.jpg
Glycine Cleavage System(Decarboxylation and Transfer of 1-Carbon Unit)


Glycine cleavage system formation of n 5 n 10 methylene thf l.jpg
Glycine Cleavage System(Formation of N5, N10-Methylene THF)


N 5 n 10 methylene tetrahydrofolate24 l.jpg
N5, N10-Methylene Tetrahydrofolate



Serine dehydratase formation of serine plp schiff base l.jpg
Serine Dehydratase(Formation of Serine-PLP Schiff Base)


Serine dehydratase formation of aminoacrylate l.jpg
Serine Dehydratase(Formation of Aminoacrylate)


Non enzymatic step conversion of aminoacrylate to pyruvate l.jpg
Non-Enzymatic Step(Conversion of Aminoacrylate to Pyruvate)



Degradation to oxaloacetate l.jpg

Degradation to Oxaloacetate

Asparagine and Aspartate



Degradation to a ketoglutarate l.jpg

Degradation to a-Ketoglutarate

Arginine, Glutamate, Glutamine, Histidine and Proline




N 5 formimino tetrahydrofolate l.jpg
N5-Formimino Tetrahydrofolate



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