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Metabolic Breakdown of Individual Amino Acids. to Citric Acid Cycle Intermediates or their Precursors. Glucogenic Pyruvate – a -Ketoglutarate Succinyl-CoA Fumarate Oxaloacetate. Ketogenic Acetyl-CoA Acetoacetate. Products of Amino Acid Breakdown.

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metabolic breakdown of individual amino acids

Metabolic Breakdown of Individual Amino Acids

to

Citric Acid Cycle Intermediates

or

their Precursors

products of amino acid breakdown
Glucogenic

Pyruvate

– a-Ketoglutarate

Succinyl-CoA

Fumarate

Oxaloacetate

Ketogenic

Acetyl-CoA

Acetoacetate

Products of Amino Acid Breakdown
slide3

Animals cannot carryout net synthesis of precursors of gluconeogenesis from acetyl-CoA or acetoacetate

degradation to pyruvate

Degradation to Pyruvate

Alanine, Cysteine, Glycine, Serine and Threonine

cysteine

Cysteine

(Various Routes)

glycine serine

Glycine —> Serine

Serine Hydroxymethyl Transferase

threonine serine

Threonine —> Serine

Serine Hydroxymethyl Transferase

(PLP and C–C Bond Cleavage)

source of n 5 n 10 methylene tetrahydrofolate

Source ofN5, N10-Methylene Tetrahydrofolate

Glycine Cleavage System

Glycine Decarboxylase Multienzyme Complex

or

Glycine Synthase (reverse direction)

glycine cleavage system
Glycine Cleavage System
  • P-Protein: PLP-dependent glycine decarboxylase
  • H-Protein: lipoamide-containing protein
  • T-Protein: THF-requiring enzyme
  • L-Protein: NAD+-dependent FAD-requiring dihydrolipoyl dehydrogenase
degradation to oxaloacetate

Degradation to Oxaloacetate

Asparagine and Aspartate

degradation to a ketoglutarate

Degradation to a-Ketoglutarate

Arginine, Glutamate, Glutamine, Histidine and Proline

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