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Metabolic Breakdown of Individual Amino Acids






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Metabolic Breakdown of Individual Amino Acids. to Citric Acid Cycle Intermediates or their Precursors. Glucogenic Pyruvate – a -Ketoglutarate Succinyl-CoA Fumarate Oxaloacetate. Ketogenic Acetyl-CoA Acetoacetate. Products of Amino Acid Breakdown.
Metabolic Breakdown of Individual Amino Acids

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Slide 1

Metabolic Breakdown of Individual Amino Acids

to

Citric Acid Cycle Intermediates

or

their Precursors

Slide 2

Glucogenic

Pyruvate

– a-Ketoglutarate

Succinyl-CoA

Fumarate

Oxaloacetate

Ketogenic

Acetyl-CoA

Acetoacetate

Products of Amino Acid Breakdown

Slide 3

Animals cannot carryout net synthesis of precursors of gluconeogenesis from acetyl-CoA or acetoacetate

Slide 4

Conversion of Pyruvate and Oxaloacetate to PEP(Gluconeogenesis)

Slide 5

Degradation to Pyruvate

Alanine, Cysteine, Glycine, Serine and Threonine

Slide 6

Alanine

Slide 7

Cysteine

(Various Routes)

Slide 8

Glycine, Threonine and Serine

Slide 9

Glycine —> Serine

Serine Hydroxymethyl Transferase

Slide 10

Formation of Glycine-PLP Schiff Base

Slide 11

Formation of Ketimine

Slide 12

Formation of Serine

Slide 13

Threonine —> Serine

Serine Hydroxymethyl Transferase

(PLP and C–C Bond Cleavage)

Slide 14

Formation of Threonine-PLP Schiff Base

Slide 15

Formation of Ketimine

Slide 16

Formation of Serine

Slide 17

Summary

Slide 18

N5, N10-Methylene Tetrahydrofolate

Slide 19

Source ofN5, N10-Methylene Tetrahydrofolate

Glycine Cleavage System

Glycine Decarboxylase Multienzyme Complex

or

Glycine Synthase (reverse direction)

Slide 20

Glycine Cleavage System

  • P-Protein: PLP-dependent glycine decarboxylase

  • H-Protein: lipoamide-containing protein

  • T-Protein: THF-requiring enzyme

  • L-Protein: NAD+-dependent FAD-requiring dihydrolipoyl dehydrogenase

Slide 21

Glycine Cleavage System (Formation of Glycine-PLP Schiff Base)

Slide 22

Glycine Cleavage System(Decarboxylation and Transfer of 1-Carbon Unit)

Slide 23

Glycine Cleavage System(Formation of N5, N10-Methylene THF)

Slide 24

N5, N10-Methylene Tetrahydrofolate

Slide 25

Elimination of Water from Serine

Serine Dehydratase

Slide 26

Serine Dehydratase(Formation of Serine-PLP Schiff Base)

Slide 27

Serine Dehydratase(Formation of Aminoacrylate)

Slide 28

Non-Enzymatic Step(Conversion of Aminoacrylate to Pyruvate)

Slide 29

Summary

Slide 30

Degradation to Oxaloacetate

Asparagine and Aspartate

Slide 31

Asparagine —> Aspartate —> Oxaloacetate

Slide 32

Degradation to a-Ketoglutarate

Arginine, Glutamate, Glutamine, Histidine and Proline

Slide 33

Arginine and Proline

Slide 34

Histidine

Slide 35

N5-Formimino Tetrahydrofolate

Slide 36

Glutamate and Glutamine


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