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Metabolic Breakdown of Individual Amino Acids






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Metabolic Breakdown of Individual Amino Acids. to Citric Acid Cycle Intermediates or their Precursors. Glucogenic Pyruvate – a -Ketoglutarate Succinyl-CoA Fumarate Oxaloacetate. Ketogenic Acetyl-CoA Acetoacetate. Products of Amino Acid Breakdown.
Metabolic Breakdown of Individual Amino Acids

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Metabolic breakdown of individual amino acids l.jpgSlide 1

Metabolic Breakdown of Individual Amino Acids

to

Citric Acid Cycle Intermediates

or

their Precursors

Products of amino acid breakdown l.jpgSlide 2

Glucogenic

Pyruvate

– a-Ketoglutarate

Succinyl-CoA

Fumarate

Oxaloacetate

Ketogenic

Acetyl-CoA

Acetoacetate

Products of Amino Acid Breakdown

Slide3 l.jpgSlide 3

Animals cannot carryout net synthesis of precursors of gluconeogenesis from acetyl-CoA or acetoacetate

Conversion of pyruvate and oxaloacetate to pep gluconeogenesis l.jpgSlide 4

Conversion of Pyruvate and Oxaloacetate to PEP(Gluconeogenesis)

Degradation to pyruvate l.jpgSlide 5

Degradation to Pyruvate

Alanine, Cysteine, Glycine, Serine and Threonine

Alanine l.jpgSlide 6

Alanine

Cysteine l.jpgSlide 7

Cysteine

(Various Routes)

Glycine threonine and serine l.jpgSlide 8

Glycine, Threonine and Serine

Glycine serine l.jpgSlide 9

Glycine —> Serine

Serine Hydroxymethyl Transferase

Formation of glycine plp schiff base l.jpgSlide 10

Formation of Glycine-PLP Schiff Base

Formation of ketimine l.jpgSlide 11

Formation of Ketimine

Formation of serine l.jpgSlide 12

Formation of Serine

Threonine serine l.jpgSlide 13

Threonine —> Serine

Serine Hydroxymethyl Transferase

(PLP and C–C Bond Cleavage)

Formation of threonine plp schiff base l.jpgSlide 14

Formation of Threonine-PLP Schiff Base

Formation of ketimine15 l.jpgSlide 15

Formation of Ketimine

Formation of serine16 l.jpgSlide 16

Formation of Serine

Summary l.jpgSlide 17

Summary

N 5 n 10 methylene tetrahydrofolate l.jpgSlide 18

N5, N10-Methylene Tetrahydrofolate

Source of n 5 n 10 methylene tetrahydrofolate l.jpgSlide 19

Source ofN5, N10-Methylene Tetrahydrofolate

Glycine Cleavage System

Glycine Decarboxylase Multienzyme Complex

or

Glycine Synthase (reverse direction)

Glycine cleavage system l.jpgSlide 20

Glycine Cleavage System

  • P-Protein: PLP-dependent glycine decarboxylase

  • H-Protein: lipoamide-containing protein

  • T-Protein: THF-requiring enzyme

  • L-Protein: NAD+-dependent FAD-requiring dihydrolipoyl dehydrogenase

Glycine cleavage system formation of glycine plp schiff base l.jpgSlide 21

Glycine Cleavage System (Formation of Glycine-PLP Schiff Base)

Glycine cleavage system decarboxylation and transfer of 1 carbon unit l.jpgSlide 22

Glycine Cleavage System(Decarboxylation and Transfer of 1-Carbon Unit)

Glycine cleavage system formation of n 5 n 10 methylene thf l.jpgSlide 23

Glycine Cleavage System(Formation of N5, N10-Methylene THF)

N 5 n 10 methylene tetrahydrofolate24 l.jpgSlide 24

N5, N10-Methylene Tetrahydrofolate

Elimination of water from serine l.jpgSlide 25

Elimination of Water from Serine

Serine Dehydratase

Serine dehydratase formation of serine plp schiff base l.jpgSlide 26

Serine Dehydratase(Formation of Serine-PLP Schiff Base)

Serine dehydratase formation of aminoacrylate l.jpgSlide 27

Serine Dehydratase(Formation of Aminoacrylate)

Non enzymatic step conversion of aminoacrylate to pyruvate l.jpgSlide 28

Non-Enzymatic Step(Conversion of Aminoacrylate to Pyruvate)

Summary29 l.jpgSlide 29

Summary

Degradation to oxaloacetate l.jpgSlide 30

Degradation to Oxaloacetate

Asparagine and Aspartate

Asparagine aspartate oxaloacetate l.jpgSlide 31

Asparagine —> Aspartate —> Oxaloacetate

Degradation to a ketoglutarate l.jpgSlide 32

Degradation to a-Ketoglutarate

Arginine, Glutamate, Glutamine, Histidine and Proline

Arginine and proline l.jpgSlide 33

Arginine and Proline

Histidine l.jpgSlide 34

Histidine

N 5 formimino tetrahydrofolate l.jpgSlide 35

N5-Formimino Tetrahydrofolate

Glutamate and glutamine l.jpgSlide 36

Glutamate and Glutamine


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