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Metabolic Breakdown of Individual Amino Acids PowerPoint PPT Presentation


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Metabolic Breakdown of Individual Amino Acids. to Citric Acid Cycle Intermediates or their Precursors. Glucogenic Pyruvate – a -Ketoglutarate Succinyl-CoA Fumarate Oxaloacetate. Ketogenic Acetyl-CoA Acetoacetate. Products of Amino Acid Breakdown. - PowerPoint PPT Presentation

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Metabolic Breakdown of Individual Amino Acids

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Metabolic breakdown of individual amino acids l.jpg

Metabolic Breakdown of Individual Amino Acids

to

Citric Acid Cycle Intermediates

or

their Precursors


Products of amino acid breakdown l.jpg

Glucogenic

Pyruvate

–a-Ketoglutarate

Succinyl-CoA

Fumarate

Oxaloacetate

Ketogenic

Acetyl-CoA

Acetoacetate

Products of Amino Acid Breakdown


Slide3 l.jpg

Animals cannot carryout net synthesis of precursors of gluconeogenesis from acetyl-CoA or acetoacetate


Conversion of pyruvate and oxaloacetate to pep gluconeogenesis l.jpg

Conversion of Pyruvate and Oxaloacetate to PEP(Gluconeogenesis)


Degradation to pyruvate l.jpg

Degradation to Pyruvate

Alanine, Cysteine, Glycine, Serine and Threonine


Alanine l.jpg

Alanine


Cysteine l.jpg

Cysteine

(Various Routes)


Glycine threonine and serine l.jpg

Glycine, Threonine and Serine


Glycine serine l.jpg

Glycine —> Serine

Serine Hydroxymethyl Transferase


Formation of glycine plp schiff base l.jpg

Formation of Glycine-PLP Schiff Base


Formation of ketimine l.jpg

Formation of Ketimine


Formation of serine l.jpg

Formation of Serine


Threonine serine l.jpg

Threonine —> Serine

Serine Hydroxymethyl Transferase

(PLP and C–C Bond Cleavage)


Formation of threonine plp schiff base l.jpg

Formation of Threonine-PLP Schiff Base


Formation of ketimine15 l.jpg

Formation of Ketimine


Formation of serine16 l.jpg

Formation of Serine


Summary l.jpg

Summary


N 5 n 10 methylene tetrahydrofolate l.jpg

N5, N10-Methylene Tetrahydrofolate


Source of n 5 n 10 methylene tetrahydrofolate l.jpg

Source ofN5, N10-Methylene Tetrahydrofolate

Glycine Cleavage System

Glycine Decarboxylase Multienzyme Complex

or

Glycine Synthase (reverse direction)


Glycine cleavage system l.jpg

Glycine Cleavage System

  • P-Protein: PLP-dependent glycine decarboxylase

  • H-Protein: lipoamide-containing protein

  • T-Protein: THF-requiring enzyme

  • L-Protein: NAD+-dependent FAD-requiring dihydrolipoyl dehydrogenase


Glycine cleavage system formation of glycine plp schiff base l.jpg

Glycine Cleavage System (Formation of Glycine-PLP Schiff Base)


Glycine cleavage system decarboxylation and transfer of 1 carbon unit l.jpg

Glycine Cleavage System(Decarboxylation and Transfer of 1-Carbon Unit)


Glycine cleavage system formation of n 5 n 10 methylene thf l.jpg

Glycine Cleavage System(Formation of N5, N10-Methylene THF)


N 5 n 10 methylene tetrahydrofolate24 l.jpg

N5, N10-Methylene Tetrahydrofolate


Elimination of water from serine l.jpg

Elimination of Water from Serine

Serine Dehydratase


Serine dehydratase formation of serine plp schiff base l.jpg

Serine Dehydratase(Formation of Serine-PLP Schiff Base)


Serine dehydratase formation of aminoacrylate l.jpg

Serine Dehydratase(Formation of Aminoacrylate)


Non enzymatic step conversion of aminoacrylate to pyruvate l.jpg

Non-Enzymatic Step(Conversion of Aminoacrylate to Pyruvate)


Summary29 l.jpg

Summary


Degradation to oxaloacetate l.jpg

Degradation to Oxaloacetate

Asparagine and Aspartate


Asparagine aspartate oxaloacetate l.jpg

Asparagine —> Aspartate —> Oxaloacetate


Degradation to a ketoglutarate l.jpg

Degradation to a-Ketoglutarate

Arginine, Glutamate, Glutamine, Histidine and Proline


Arginine and proline l.jpg

Arginine and Proline


Histidine l.jpg

Histidine


N 5 formimino tetrahydrofolate l.jpg

N5-Formimino Tetrahydrofolate


Glutamate and glutamine l.jpg

Glutamate and Glutamine