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2 nd CNN. Brain focused treatment. Department of Urology, Kyoto Prefectural University of Medicine. Akihiro Kawauchi, M.D., Ph.D. Nocturnal enuresis : Voiding during sleep. Causes: Sleep (including nocturnal polyuria), bladder or both. Brain focused treatment?.

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2nd CNN

Brain focused treatment

Department of Urology,

Kyoto Prefectural University of Medicine

Akihiro Kawauchi, M.D., Ph.D.


Nocturnal enuresis voiding during sleep
Nocturnal enuresis:Voiding during sleep

  • Causes: Sleep (including nocturnal polyuria), bladder or both




The health-related quality of life in enuretic children evaluated before and after treatment (Kid-kindle)

P value**

Before treatment vs. Healthy volunteers

P value*

Before vs. after treatment

After

treatment

Before

treatment

Healthy

volunteers

Domain

0.36

16.9±2.6

0.08

Physical well-being

17.3±2.0

16.6±2.6

17.7±2.2

17.3±2.3

0.08

0.38

Emotional well-being

17.1±2.4

12.8±3.8

0.26

Self-esteem

12.5±4.1

0.46

13.2±3.8

0.02

14.7±3.4

15.7±2.8

15.7±2.9

Family

0.04

0.27

16.2±2.9

16.7±2.8

0.97

Friend

16.2±1.1

0.16

0.34

14.2±3.2

14.3±1.1

School

13.7±3.1

* paired-t test

* * t test

J Urol, in press


The health-related quality of life in mothers of enuretic children evaluated before and after treatment (SF36)

Beforetreatment

P value**

Before treatment vs. Healthy volunteers

P value*

Before vs. after treatment

After treatment

Healthy

volunteers

Domain

92.5±8.8

Physical functioning

91.9±9.1

91.7±10.5

0.58

0.89

91.2±15.5

Role physical

0.35

0.44

88.9±17.3

90.7±13.5

72.8±19.8

71.9±22.2

73.1±17.0

0.91

0.68

Body pain

0.69

67.2±16.2

65.3±16.0

0.71

66.2±17.1

General health

0.03

0.01

Vitality

60.1±10.1

66.1±16.6

64.8±17.9

0.86

89.5±16.3

89.1±15.8

88.4±17.2

0.66

Social functioning

Role emotional

88.6 ±17.7

89.9 ±17.1

0.62

90.4 ±16.3

0.84

0.54

70.8±17.2

72.6±16.8

0.48

Mental health

72.4±17.6

* * t test

* paired-t test

J Urol, in press


The health-related quality of life in mothers of enuretic children evaluated with STAI and SDS before and after treatment

P value**

Before treatment vs. Healthy volunteers

P value*

Before vs. after treatment

Beforetreatment

After treatment

Healthy

volunteers

STAI

0.02

0.003

37.3 ±12.8

state

42.0 ±7.8

38.7 ±11.2

trait

0.22

37.7 ±14.2

39.9 ±9.1

37.9 ±11.5

0.20

SDS

0.40

38.7 ±8.2

38.4 ±8.5

0.49

38.0 ±7.3

* paired-t test

* * t test

J Urol, in press


Sleep and bladder children evaluated with STAI and SDS before and after treatment


Dynamic change in bladder capacities in 24 nonenuretics and 36 enuretics
Dynamic change in bladder capacities in children evaluated with STAI and SDS before and after treatment24 nonenuretics and 36 enuretics

Capacity (ml)

Nocturnal

Bladder Capacity

(NBC)

Enuretic

Bladder Capacity

(EBC)

Functional

Bladder Capacity

(FBC)

Urology, 2003


Changes in enuretic bladder capacity ebc during alarm therapy
Changes in enuretic bladder capacity (EBC) during alarm therapy

P<0.001

P<0.05

P<0.01

EBC (ml)

Enuresis, 1997



Effect of ddavp on awakening ability
Effect of DDAVP on awakening ability therapy

DDAVP 20μg

June/1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16

Time

9

10

11

12

1

2

3

4

5

6

7

8

Am

○:Awakening without wetting×:Bedwetting


Latero-dorsal tegmental nucleus (LDT) response to administration of DDAVP

intravenous injection

administration

Direct

Urology 2004



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