Epidemiology. Rare disease incidence in the US 19/million/year and prevalence of 19-75/100,000Rare in childrenPeak between age 35-65More women affectedFamily h/o other auto immune diseasesEthnic background influence survival and disease manifestation.. Clinical features. Raynaud'sTypical skin
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
1. Systemic sclerosis Also called scleroderma
Multisystem disease of unknown etiology
Pathogenesis include immune system activation , endothelial activation , and fibroblast activation
this results in small blood vessels damage and tissue fibrosis.
2. Epidemiology Rare disease incidence in the US 19/million/year and prevalence of 19-75/100,000
Rare in children
Peak between age 35-65
More women affected
Family h/o other auto immune diseases
Ethnic background influence survival and disease manifestation.
3. Clinical features Raynaud’s
Typical skin changes
Esophageal and small bowel dysfunction
Interstitial lung disease
4. What is Raynaud’s Phenomenon Reversible skin color changes:White to blue to red
Due to vasospasm
Induced by cold of emotion
5. Raynaud’s :Pallor phase