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(A) Rotarod test. Day 2. Day 3. Day 4. Day 5. Day 1. Test phase Max :32 rpm Acceleration mode (6 repetitions). Training phase 120 s at 5 rpm Constant mode (5 repetitions). (B) MBx and electrophysiology. Week 7. Week 15. Week 23. MBx -16th week. MBx – 24th Week.

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slide1

(A) Rotarod test

Day 2

Day 3

Day 4

Day 5

Day 1

Test phase

Max :32 rpm

Acceleration mode

(6 repetitions)

Training phase

120 s at 5 rpm

Constant mode

(5 repetitions)

(B) MBx and electrophysiology

Week 7

Week 15

Week 23

MBx -16th

week

MBx – 24th

Week

MBx -8-9th

week

Supplementary Figure 1

Week 9, 16 & 23

Week 37

Schematic time scale of experiments. A: Rotarod. B: Muscle biopsy (MBx) and electrophysiology. rpm = rotations per minute

Electrophysiology

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